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manufacturer of Leuprorelin Acetate reasonable price of 74381-53-6
manufacturer of Leuprorelin Acetate reasonable price of 74381-53-6

manufacturer of Leuprorelin Acetate reasonable price of 74381-53-6

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1 Gram

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  • Min.Order :1 Gram
  • Purity: 99.0% min
  • Payment Terms : L/C,T/T

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reasonable price of 74381-53-6 manufacturer of Leuprorelin Acetate 74381-53-6

Quick Details

  • Appearance:off-white to white powder
  • Application:For treatment of prostate cancer, endometriosis, uterine fibroids and premature puberty
  • PackAge:1g
  • ProductionCapacity:20|Kilogram|Year
  • Storage:2-8℃
  • Transportation:2-8℃

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Competetive price.

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manufacturer of Leuprorelin Acetate reasonable price of 74381-53-6

 

Product Name: Leuprorelin acetate
Synonyms: leutenizinghormone-releasingfactor(pig),6-d-leucine-9-(n-ethyl-l-prolinamid;lupron;tap-144;6-D-Leucine-9-(N-ethyl-L-prolinamide)-10-deglycinamideluteinizing Hormone-Releasing Factor Acetate(Pig);Abbott 43818;Procren Depot;Procrin;Prostap
CAS: 74381-53-6
MF: C59H84N16O12.C2H4O2
MW: 1269.46
EINECS: 686-285-8
Product Categories: -;Bases & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Nucleotides;Pharmaceuticals;Gonadotropin-releasing hormone (GnRH);Anti-cancer&immunity;Organics
Mol File: 74381-53-6.mol
Leuprorelin acetate Structure
 
Leuprorelin acetate Usage And Synthesis
Anti-cancer drugs Leuprolide acetate is a commonly used hormone anti-cancer drug, , it is a acetate of leuprolide which is a nonapeptide synthetic analogue of LHRH( one kind decapeptide), it is a LH-RH antagonist, LHRH is produced by the hypothalamus, it can promote pituitary for the release of gonadotropins and follicle-stimulating hormone (FSH) and luteinizing hormone (LH). This product’s structure is similar to LHRH, its acting on the anterior pituitary which prompts FSH, LH release function, increases serum concentrations of testosterone and dihydro testosterone. It is used as maintenance therapy for advanced prostate cancer clinically, but in about one week after use of the product, the number of active receptors will be reduced, and gonadotropin secretion will be reduced.After 2 to 4 weeks, the concentration of testosterone and dihydro testosterone can be reduced to castration levels. After the withdrawal, gonadotropin and androgen concentrations can be recovered to normal. 
Note that this product is not effective when administered orally, subcutaneous or intramuscular administration has good absorption. T1/2 of parenteral administration is 3 h. There is no accumulation in the body, unchanged drugs and its metabolites in urine excretion rates are2.9% and 1.5%, respectively. Ethanol can enhance the role of this product, the course of treatment should not drink, in case it is difficult to control the incidence of adverse reactions. In the first week of the course of treatment ,patients should try to be hospitalized for monitoring, choose an experienced physician to guide treatment to prevent severe neurological complications, urinary tract obstruction. Injection site should often vary. 
The above information is edited by the chemicalbook of Tian Ye.
Description Leuprolide acetate is a potent analog of LH-RH useful in achieving a medical castration in the treatment of advanced prostate cancer. It has also been investigated for the treatment of advanced breast cancer.
Chemical Properties Fluffy Solid
Originator Takeda (Japan)
Uses Synthetic nonapeptide agonist analog of LH-RH. Antineoplastic (hormonal).
Definition ChEBI: An acetate salt obtained by combining the nonapeptide leuprolide with acetic acid. A long lasting GnRH analog, LH-Rh agonist. It is a synthetic nonapeptide analogue of gonadotropin-releasing hormone, and is used as a subcutaneous hydrogel implant for the t eatment of prostate cancer and for the suppression of gonadal sex hormone production in children with central precocious puberty.

Details:

Product Name

Leuprorelin Acetate

CAS#

74381-53-6

Sequence

Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEt

Certificate

N/A

Status

Commercialized

Stock

Available

Packing

1g/bottle, 5g/bottle,10g/bottle,50g/bottle

Storage Temperature

2-8℃

 

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