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Hot sale 88495-63-0 Reliable quality 88495-63-0 Artesunate 88495-63-0
Hot sale 88495-63-0Reliable quality 88495-63-0Artesunate 88495-63-0
Artemisinin is a commonly used antiparasitic drug, in order to reduce artemisinin succinic acid monoester, is a derivative of artemisinin with a polysane ester structure, the role of malaria parasites than artemisinin, anti-chloroquine strains are also effective. Acting on the red endocrine cleavage of the malaria parasite, by reducing artemisinin inhibits cytomegic oxidase, to inhibit the function of a food bubble membrane in the malaria parasite's epidermis, mitochondrial membrane cytomelet oxidase, thus blocking the supply of nutrients to the host cell pulp. The asexual body of the malaria parasite has a strong killing effect, works quickly, can quickly control the onset of malaria, has a better effect on cerebral malaria, Plasmodium falciparum and inter-day malaria, and is equally effective against the chloroquine strain of Plasmodium falciparum. In particular, the effect of cerebral malaria is more significant, it can quickly control the onset of malaria, but it is not effective for Plasmodium falciparum ligands. T1/2 is shorter than artemisinin ether, and blood concentrations drop rapidly after intravenous injection, with T1/2 being around 30min. Widely distributed in the body, with higher content in intestines, liver and kidneys. Urine, feces excretion only a small amount, mainly for metabolic transformation. Clinically suitable for the rescue of patients with acute malaria, it can be used as the first choice drug for the treatment of cerebral malaria and all kinds of dangerous malaria patients. But the high rekindling rate is its disadvantage. No adverse reactions were seen under the recommended amount of treatment; If the use of large doses may appear peripheral mesh red blood cells over-reduced, after discontinuation can return to normal. Whether it is teratogenic for pregnant women within 2 months of pregnancy is subject to further study.
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