CasNo.33089-61-1,Manufacturer Wholesale Price Amitraz with High Quality CAS 33089-61-1,(33089-61-1) Suppliers

1 Kilogram	FOB Price:USD 4.8000 -5.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Amitraz 33089-61-1 Amitraz powder

Quick Details

Appearance:White powder
Application:Blood lipid regulation, anti - atherosclerosis drugs
PackAge:25KG/DRUM
ProductionCapacity:1000|Kilogram|Year
Storage:Store at +4°C
Transportation:General cargo transport

Superiority:

We are concentrating on APIs and pharmaceutical intermediates.

It is made obtainable from us at the most reasonable rate.

Our Service:

1. Rich experience: Our company is a professional production leading factory in China in pharmaceutical area of manyyears.

2. Top quality: High quality guaranteed, once any problem is found, the package would be reshipped for you .

3. Security Shipping: Shipping by express (FedEx,UPS,DHL,EMS), by air, by sea. The most professional forwarder would be recommanded for you.

4. Fast delivery: We have stock, so we can delivery quickly once payment is received.

5. Quality service: We will give you warm after-sale service,if any question we will reply you within 24 hours.

6. Competitive prices: A discount would be given when you make a large order.

Details:

Company Profile:

Company name: Hanways ChemPharm Co., Ltd.

Year Establishment: 2009

Location: 18-1-802, Green Garden, Jianghan District, Wuhan 430023, China

Main product:
- API: Antiobesity; Oncology; Antiviral; Cardiovascular; Antibiotics; Antidiabetics and others
- Peptides
- Hormones
- Intermediates

Product Name: Amitraz

CAS: 33089-61-1

MF: C19H23N3

MW: 293.41

EINECS: 251-375-4

Appearance: White powder

Amitraz is quickly hydrolyzed in an acid environment when it is orally administrated, due to its instability in this environment. The hydrolysis in a low pH generates the compound 2,4-dimethylphenyl formamide, which is stable in an acid environment. This substance can still be hydrolyzed, generating 2,4-dimethylaniline. Absorption is effective through the skin, which may be major or minor depending on its integrity, the occurrence of injuries, and inflammation. After reaching the blood stream, the drug reaches the highest plasmatic level in up to two hours. The biotransformation occurs in the liver, generating the active metabolite BTS 27271, the most important pharmacologically, because it acts directly in the regulation of the insulin and glucagon secretion by binding to the α2A and α2D-adrenergic receptors, inhibiting insulin and stimulating glucagon secretion, resulting in hyperglycemia. Metabolites are excreted in bile and urine.

In insects, formamidines such as chlordimeform and amitraz operate its toxic effects by interacting with octopaminergic receptors in the central nervous system. The mechanisms by which the deleterious effects of amitraz in mammals are determined are based on its agonistic action on α2-adrenergic receptors and inhibitory action over the monoamine oxidase (MAO), but there are reports of various action pathways, such as: H1 histamine receptor inhibition, prostaglandin synthase inhibition, adenylyl cyclase inhibition, voltage-gated calcium channels activation, reactive oxygen species generation, cell death induction and endocrine disruptions. Amitraz is also related to the emergence of neurotoxic effects and modifications in the reproductive sphere in rats.