Best price of/High ...

Best price of/High purity in bulk supply 95% Kovidone VA64 25086-89-9

Best price of/High purity in bulk supply 95% Kovidone VA64 25086-89-9

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  • Min.Order :0 Metric Ton
  • Purity: 95%
  • Payment Terms : L/C,T/T

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High purity 95% Kovidone VA64 25086-89-9 in bulk supply Best price of PVP VA64

Quick Details

  • Appearance:White or off white powder
  • Application:Pharmaceutical & Health Care
  • PackAge:net 20kg fibre drum
  • ProductionCapacity:200|Metric Ton|Month
  • Storage:
  • Transportation:By sea or by air

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Best price of/High purity in bulk supply 95% Kovidone VA64 25086-89-9 
CAS: 25086-89-9
MF: C30H45N3O9X2
MW: 591.69
EINECS:
Product Categories: Hydrophobic Polymers;Materials Science;Hair Care;Polymer Science;Vinylpyridine and Vinypyrrolidone Polymers;API;Polymers;Hydrophobic Polymers;Poly(vinylpyrrolidone);Vinylpyridine and Vinypyrrolidone Polymers
Mol File: 25086-89-9.mol
Poly(1-vinylpyrrolidone-co-vinyl acetate) Structure
Poly(1-vinylpyrrolidone-co-vinyl acetate) Chemical Properties
density  1.27 g/mL at 25 °C(lit.)
refractive index  1.4300 to 1.4380
Fp  72 °F
solubility  Greater than 10% solubility in 1,4-butanediol, glycerol, butanol, chloroform, dichloromethane, ethanol (95%), glycerol, methanol, polyethylene glycol 400, propan-2-ol, propanol, propylene glycol, and water. Less than 1% solubility in cyclohexane, diethyl ether, liquid paraffin, and pentane.
form  powder
Stability: Stable. Combustible, especially in powdered form. Incompatible with strong oxidising agents, strong reducing agents.
EPA Substance Registry System Vinyl acetate N-vinyl-pyrrolidone polymer (25086-89-9)KoVidone VA64 possesses excellent powder and film properties for broad application in the pharmaceutical field.

Details:

THE COMPANY
 
•  Publicly traded company on the Shenzhen stock exchange (stock code 300109)
•  First domestic company to develop and manufacture PVP and PVM/MA products
•  3rd Largest Global PVP manufacturer
•  2nd Largest Global PVM/MA manufacturer
•  International subsidiaries in China,Europe and Japan
•  Global distribution network
 
  OUR PRODUCTS
 
•  KoVidone® and PolyKoVidone® line of products representing Povidone, Crospovidone and Copovidone pharmaceutical excipients. 
•  OraRez® line of PVM/MA copolymer and derivatives representing functional polymers for bioadhesive/mucoadhesive applications. 
•  KoVidone®-I (PVP-I) broad spectrum biocidal, antifungal and antiviral agent. 
•  Pharmaceutical solvents and intermediates.
 
  QUALITY
 
•  First Chinese manufacturer to be EXCiPACTTM GMP certified
•  All pharmaceutical products manufactured under strict cGMP guidelines
•  All pharma products handled and packaged in class D cleanrooms
•  State of the art manufacturing facility (commissioned 2013)
•  QC equipment and test methods fully validated and fully audit trail compliant
 
ENVIRONMENTAL RESPONSIBILITY
 
•  Fully compliant with government requirements and regulations
•  Real time monitoring of waste streams
•  100% recycling of processing water 
•  Complete conversion from coal to natural gas
•  Focus on developing green production processes
 
  CUSTOMER and TECHNICAL SERVICE
 
•  Technical Research Center to assist our customer with formulation development
•  New R&D center commissioned in 2018 having integrated R&D and pilot manufacturing
•  Customer partnering to develop new opportunities
•  Strong customer and quality management services to assist our customers
 
 
 

KoVidone® VA64  

Product name     KoVidone® VA64 Copovidone

USP/EP name     Copovidone, Copovidonum

INCI/CTFA        VP/VA copolymer 60/40

CAS NO.         25086-89-9

K value          25.2-30.8 (Copovidone 28), 27.0-33.0 (Copovidone 30)

Properties       Hygroscopic capacity lower than KoVidone® K30; Soluble in water, alcohol and many other organic solvents; Glass transition temperature(Tg) lower than KoVidone® K30; Forms transparent, water removable films.

The content of vinyl acetate    35.3-41.0%

 

Applications

 

KoVidone® VA64 possesses excellent powder and film properties for broad application in the pharmaceutical field:

 

·       Water soluble tablet binder; suitable for wet or dry granulation and direct compression processes, improves particle compressibility.

·       Film-former; permeable film coating for tablet and sugar coatings to protect against splitting, decrease moisture sensitivity and provide good film adhesiveness, elasticity, and hardness.

·       Porogenic agent; for use in taste-masking and component of the matrix material used in controlled-release formulation.

·       Solubilizing agents; for solid dispersion processes to enhancing bioavailability and improve drug solubility. For use in both Hot Melt Extrusion and Spray Solvent Drying

 

The addition of KoVidone® VA64 to HPMC film coating solutions can effectively reduce the viscosity of the HPMC solution while enhancing resultant film characteristics by improving film formation, flexibility and gloss.

 

Nimodipine- KoVidone® VA64 solid dispersion HME process

Due to its lower glass transition temperature Tg, KoVidone® VA64 is especially suited for developing solid dispersion drug systems via hot melt extrusion processing.

 

Hot melt extrusion (HME) technology is a new technique to prepare pharmaceutical dosage forms. HME shows unique advantages and is used to: improve the dissolution rate of extremely poorly soluble drugs..

 

HME uses no solvent in the production process, the drug is hot melt extruded with a suitable polymer carrier (Kovidone® VA64). The extrusion process converts crystalline drugs to their amorphous form (Solid Dispersion) that helps to improve both drug solubility and bioavailability and increase the stability of the finished dosage form.

 

Solid Dispersions can also be produced via Spray Solvent Drying whereby the Kovidone and poory soluble active are dissolved in a suitable solvent and spray dried. The resulting Solid Dispersion is similar to that achieved with HME.

 

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