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Lenvatinib Intermediate Lenvatinib Lenvatinib mesylate
Name | 1,4-Dihydro-7-methoxy-4-oxo-6-quinolinecarboxylic acid methyl ester |
Molecular Formula | C12H11NO4 | |
Molecular Weight | 233.22 | |
CAS Registry Number | 205448-65-3 |
Methyl 4-((2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-ylidene)methylamino)-2-methoxybenzoate CAS:205448-64-2
Name | Lenvatinib mesylate | |
Synonyms | 4-[3-Chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxamide monomethanesulfonate; E 7080 mesylate |
Molecular Formula | C21H19ClN4O4.CH4O3S | |
Molecular Weight | 522.96 | |
CAS Registry Number | 857890-39-2 |
Tests |
Specifications |
Results |
Description |
White or almost white powder, hygroscopic. |
Conform |
Identification |
LC identification test,Conform |
Conform |
A reddish violet color is produced, Conform |
Conform |
|
Meets the requirements of the tests for Sulfate,Conform |
Conform |
|
Specific optical rotation |
-78º~ -90º |
-82º |
PH(0.5%) |
5.0~7.5 |
6.4 |
Loss on drying |
≤7.0% |
4.2% |
Sulphated ash |
≤0.75% |
0.22% |
Phenylalanine |
9.0%~12.0% |
10.2% |
Total viable aerobic count |
≤10cfu/g |
Conform |
Potency(Dried basis) |
≥6000iu/mg |
8085iu/mg |
Particle size |
99.0%: not more than 20µm by vol. 90.0%: not more than 15µm by vol. 75.0%: not more than 10µm by vol. 35.0%: not more than 5µm by vol. Mean diameter:not more than 10.0µm |
Conform |
HANGZHOU THINK CHEMICAL CO., LTD. (THINKCHEM) is an integrative corporation of trade, research and contract manufacture.
With about ten years of business experiences on the marketing & distribution, thinkchem specializes in exporting pharmaceuticals, veterinary drugs, feed additives, intermediates, fine chemicals, plants extracts, pesticides, food & nutrition additives.
Thinkchem is good at offering excellent outsourcing services to overseas customers as well as laboratory support.
Custom manufacture
Thinkchem is good at offering contract manufacture and custom synthesis under confidential agreement timely and effectively, and providing sales service from grams ,kilograms to multi-tons particularly for pharmaceuticals and their intermediates discovery and development. Thinkchem is equipped with modern lab apparatus including HPLC, GC. TLC AND NMR, motivated by a team of highly qualified personnel using these equipments.
Staff
Thinkchem is composed of chemical technicians, analytical chemists, organic chemists, and chemical engineers educated in leading universities in china. Our staff is supported by a group of consultants from academia with expertise in chemical synthesis and analytical chemistry.
1. Well-trained professional sales team dedicated to source, audit and export.
2. Well-trained R & D team equipped with new knowledge, new ideas and new insights to support product development and innovation.
3. Well-established partnership with major pharmaceutical and chemical companies in china.
4. Wide range of products and efficient regulatory documentation offered to customers.
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