104778-14-5 cas 104778-14-5 (3E)-3-[(3,4-dihydroxyphenyl)methylidene]-7-hydroxychromen-4-one
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Sappanone A is a homoisoflavonoid isolated from the aerial parts of Caesalpinia sappan. It inhibited the production of nitric oxide (NO), prostaglandin E2 (PGE2) and interleukin-6 (IL-6) as well as the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2) and IL-6 in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Sappanone A exhibits anti-inflammatory effect via modulation of Nrf2 and NF-κB pathways.
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