Hotsale Cycloheximide

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Shanghai Upbio Tech Co.,Ltd is a comprehensive manufacturer and an international distribution of chemicals throughout the world. Specialized in APIs, chemical intermediates, herbal extract and pharmaceutical raw materials. 

Product Name: Cycloheximide
Molecular Formula: C15H23NO4
Molecular Weight: 281.3474
CAS Registry Number: 66-81-9
EINECS: 200-636-0
Density: 1.136g/cm3
Melting point :107-114℃
Boiling point :491.8°C at 760 mmHg
Refractive index: 1.498
Flash point :251.2°C
Water solubility: 2.1 g/100 mL (2℃)
Vapour Pressur :9.81E-12mmHg at 25°C

Cycloheximide is a highly effective antibiotic with activity against mold, yeast, and phytopathogenic fungi, with lower activity against bacteria. It has been reported to inhibit the synthesis of both proteins and macromolecules, as well as affect apoptosis in eukaryotes. Inhibition of protein synthesis is believed to be mediated through DNA translation arrest, as demonstrated in ratthymocytes. Although cycloheximide has been reported to induce apoptosis in various cells, it has also been shown to inhibit or delay induced apoptosis. These observations suggest that cycloheximide's effect on apoptosis may not be solely through protein translation arrest and that other mechanisms may be involved. Cycloheximide has also been reported to inhibit FKBP12 (peptidylprolylisomerase hFKBP12, PPIase hFKBP12) via competitive inhibition.

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