Aurora Kinase Inhibitor III

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1 Gram	Negotiable

1 Gram

Negotiable

Min.Order :1 Gram
Purity: ≥98%
Payment Terms : L/C

Keywords

879127-16-9 AKI 7169 Aurora Kinase Inhibitor II

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Appearance:Solid Powder
Application:research use
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ProductionCapacity:1|Kilogram|Month
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BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. #

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Aurora kinase inhibitor III is a potent ATP-competitive aurora related kinase inhibitor with IC50 of 42 nM. Aurora kinase inhibitor III is a cell-permeable, 2,4-dianilinopyrimidine compound which has been used to study a variety of tumor types. It is selective for Aurora A over BMX, BTK, IGF-1R, c-Src, TRKB, SYK, and EGFR (IC50s = 386, 3,550, 591, 1,980, 2,510, 887, and >10,000 nM, respectively). Aurora kinase protein levels are elevated in c-myc-driven B-cell lymphomas in both mice and humans. Study of the inhibition of Aurora kinase proteins could lead to potential treatments for malignancies.

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