Somatostatin Acetate Somatotropin Release-Inhibiting Factor Regulates Endocrine System

Basic Information

Somatostatin is a kind of neurohormone with a wide range of effects. Its main function is to inhibit the basal secretion of pituitary growth hormone (GH), and also inhibit the GH secretion reaction caused by various stimulating pituitary gland, including exercise, eating, and should Excited, hypoglycemia, etc. In addition, somatostatin also inhibits the secretion of LH, FSH, TSH, PRL and ACTH. Somatostatin binds to membrane receptors of pituitary auxin cells and acts by reducing intracellular cAMP and Ca2.

In addition to the hypothalamus, other parts such as the cerebral cortex, striatum, amygdala, hippocampus, and spinal cord, sympathetic nerve, gastrointestinal, islet, kidney, thyroid and parathyroid glands are widely distributed in somatostatin. In the brain and gastrointestinal tract, 28 amino acids of GHRIH28, which is an outward extension of the N-terminus of GHRIH14, was purified. The effect of somatostatin in vitro is complicated, and it may act as a transmitter or modulate in the nervous system; somatostatin has a certain inhibitory effect on gastrointestinal motility and secretion of digestive tract hormones; it also inhibits insulin and pancreas Glucagon, renin, parathyroid hormone and calcitonin secretion.

FUNCTION&APPLICATION

1 It can inhibit the secretion of growth hormone, thyroid stimulating hormone, insulin, glucagon.

2 It can inhibit gastric acid secretion stimulated by the test meal and 5-peptide gastrin, and can inhibit the release of pepsin and gastrin.

3 It can significantly reduce visceral blood flow, reduce portal pressure, reduce blood flow and pressure of collateral circulation, reduce liver blood flow.

4 It reduce the secretion of the pancreas and the secretion of the small intestine and gallbladder, reduce the enzyme activity, and have a protective effect on pancreatic cells.

5 It can affect the absorption and nutritional function of the gastrointestinal tract.