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78916-42-4 cas 78916-42-4 Inhibitor
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BOC Sciences provides a wide range of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecule and chiral compounds. #
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Amorfrutin B is a partial agonist of the peroxisome proliferator-activated receptor γ (PPARγ; Ki = 19 nM and EC50 = 73 nM) that was first isolated from A. fruticosa. Amorfrutin B has low nanomolar binding affinity to pparγ and micromolar binding to the isotypes pparα and pparβ/δ, the binding affinity constant to ppargamma is 12 times lower than amorfrutin a, antidiabetic agent, glucose-lowering agent, antimicrobial agent. It binds to PPARα with 2.6 µM and PPARβ/δ with Ki values of 1.7 µM. Amorfrutin is a glucose-lowering agent and can improves insulin sensitivity, glucose tolerance and blood lipid variables without increase of fat storage or hepatoxicity.
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