R-406

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0 Metric Ton	Negotiable

0 Metric Ton

Negotiable

Min.Order :0 Metric Ton
Purity: 99%
Payment Terms : L/C,T/T,Other

Keywords

R-406 Tamatinib R406

Quick Details

Appearance:Off-white to white solid powder
Application:Intermediate used for preparation of prodrugs of pyrimidine-2,4-diamines as anticancer agents.
PackAge:As customer request
ProductionCapacity:100|Kilogram|Week
Storage:Store in a cool,dry place and keep away from direct strong light
Transportation:By Sea/Air/Courier

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Details:

R-406(841290-80-0)

[PRODUCTNAME]:6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one

[CATALOG NUMBER]:

[CAS NUMBER]:841290-80-0

[MOLECULAR FORMULA]:C22H23FN6O5

[MOLECULAR WEIGHT]:470.45400

[BATCH NO]: 20190218

[TEST]:SPECIFICATION

[APPEARANCE]: White Solid

[ASSAY]: 98%min

[WATER]: 0.5%max

R-406 Usage And Synthesis

Uses

Intermediate used for preparation of prodrugs of pyrimidine-2,4-diamines as anticancer agents.

Uses

R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcεRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 μM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce immune complex-mediated inflammation. In cancers characterized by over-expression of Syk, R406 can prevent signaling downstream of Syk and induce apoptosis. R406 also inhibits Syk-dependent signaling through c-Jun N-terminal kinase in rheumatoid arthritis synoviocytes, suggesting a therapeutic intervention in this autoimmune disease.[Cayman Chemical]