246246-19-5 cas 246246-19-5 Inhibitor
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AL 8810 is a prostaglandin F2a analog and a selective FP prostanoid receptor antagonist. AL-8810 produced a concentration-dependent shift in the fluprostenol concentration-response curve, without significantly decreasing the maximal response. AL-8810 has weak agonist potency with EC50 of 261 +/- 44 nM (n = 3) and Emax = 19% (relative to the full FP receptor agonist cloprostenol) in A7r5 cells and EC50 of 186 +/- 63 nM (n = 3) and Emax = 23% in 3T3 fibroblasts.
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