R406 (Tamatinib)

R406 (Tamatinib)
R406 (Tamatinib)

R406 (Tamatinib)

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1 Gram

Negotiable

  • Min.Order :1 Gram
  • Purity: 99%
  • Payment Terms : L/C,T/T,

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R-406 99%R-406 R-406 China manufacturer

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  • Appearance:
  • Application:Intermediate used for preparation of prodrugs of pyrimidine-2,4-diamines as anticancer agents.R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this actio
  • PackAge:As customer request
  • ProductionCapacity:100|Kilogram|Week
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  • Transportation:By Sea/Air/Courier

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Lorcaserin(856681-05-5)is an orally administered agent and a selective 5-HT2C receptor agonist for the treatment of obesity. It had been approved for marketing in US by FDA on 27 June in 2012. In clinical studies, lorcaserin has demonstrated efficacy in obese and overweight populations by promoting weight loss and improving metabolic parameters, and it is well tolerated.

Details:

R406

CAS: 841290-80-0
MF: C22H23FN6O5
MW: 470.459
Appearance: White powder
Assay:  99%
desnity: 1.358±0.06 g/cm3(Predicted)
Uses:   Intermediate used for preparation of prodrugs of pyrimidine-2,4-diamines as anticancer agents.R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcεRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 μM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce immune complex-mediated inflammation. In cancers characterized by over-expression of Syk, R406 can prevent signaling downstream of Syk and induce apoptosis. R406 also inhibits Syk-dependent signaling through c-Jun N-terminal kinase in rheumatoid arthritis synoviocytes, suggesting a therapeutic intervention in this autoimmune disease.

 

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