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1 Kilogram |
FOB Price:USD 135.0000 -140.0000 |
89778-27-8 High quality API Animal Pharmaceuticals
Toremifene, 2-[4-[(1Z)-4-chloro-1,2-diphenyl-1-butenyl]phenoxy]-N,N-dimethylethanamine(Fareston), differs structurally fromtamoxifen only by having a chloroethyl group (rather than anethyl group) attached to the triphenylethylene structure. Asmight be expected, the pharmacological actions of toremifeneand tamoxifen are quite similar. Toremifene is also a SERM,with estrogen antagonist action in breast tissue but agonist actionin the endometrium, on bone tissue, and on serum lipidprofiles. Recent clinical data indicate that the incidence ofendometrial cancer is lower with toremifene use than with tamoxifen. Toremifene is used in the treatment of metastaticbreast cancer in postmenopausal women.
Toremifene citrate tablets are suitable for postmenopausal women with estrogen receptor-positive or unknown metastatic breast cancer.
Note:
Patients with pre-existing endometrial hyperplasia or severe liver failure are prohibited from taking this product for a long time and who are allergic to this product.
TEST ITEMS |
SPECIFICATION |
RESULTS |
Description |
: White Crystalline Powder |
White Powder |
Identification |
: Positive |
Positive |
Assay(by HPLC) |
: 98.0~102.0% |
99.64% |
Absorbance(E1cm) |
: 465~495 |
482.5 |
Melting Point |
: 191~195°C |
193.5~195.0°C |
Loss On Drying |
: 0.5%max |
0.19% |
Specific Rotation |
: +288°~ +298° |
+290.2° |
Residue On Ignition |
: 0.1%max |
0.03% |
Related Substances |
: Total:1.5%max |
<1.3% |
|
Single:0.5%max |
<0.4% |
Residue Solvents |
: 0.2%max |
0.10% |
Heavy Metals |
: 20PPm max |
<10PPm |
Conclusion |
The specification conform with enterprise standard. |
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