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103639-04-9 Animal Pharmaceuticals High quality
Ondansetron hydrochloride is a selective 5HT3-antagonist approved for the management of nausea and vomiting induced by cancer chemotherapy and radiotherapy. It is reported to have a superior side-effect profile compared with metoclopramide, representing an important advance in the treatment of nausea and vomiting associated with chemotherapy. Ondansetron hydrochloride is the first specific 5HT3-antagonist to reach the market. It is also under investigation for a number of other indications, including anxiety and schizophrenia.
Ondansetron, granisetron, and dolasetron are three common clinical antiemetic. Ondansetron is an effective, reversible and selective serotonin (5-HT3) blocker. It have little effect for α1, α2, β1, β2-adrenergic receptor and the histamine H1, H2 receptor, which have minimal effect on H receptors, central and peripheral dopaminergic receptor antagonistic effect. It can be suppressed by the chemotherapy and radiotherapy-induced nausea and vomiting. Compared with metoclopramide, it has strong antiemetic effect without extrapyramidal reactions. . can produce rapid and strong antiemetic effect. Suitable for the treatment of nausea and vomiting, nausea, vomited by the cytotoxic chemotherapy and radiation therapy. It can also prevent and treat nausea and vomit induced by surgically .
Description |
White powder |
Complies |
Identification |
IR |
Complies |
|
HPLC |
Complies |
Heavy metal |
≤10ppm |
5ppm |
Pb |
≤3ppm |
1.5ppm |
Hg |
≤0.1ppm |
0.05ppm |
Cd |
≤1ppm |
0.2ppm |
Loss on drying |
≤0.5% |
0.12 |
Residue on lgnition |
≤0.1% |
0.03 |
Single impurity |
≤0.5% |
0.12 |
Total impurity |
≤1.0% |
0.29 |
Total bacteria |
≤1000cfu/g |
<1000 |
Yeast and Mould |
≤100 cfu/g |
<000 |
E.coli/25g |
Absent |
Absent |
Salmonella/25g |
Absent |
Absent |
Assay |
≥99.0% |
99.40% |
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