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364782-34-3 Cosmetic Raw Materials Pharmaceuticals
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Name |
Cinacalcet hydrochloride |
Cas |
364782-34-3 |
Content | 99% |
Description:
Cinacalcet Hydrochloride is a type II calcimimetic agent which controls calcium levels in cells by allosteric activation of CaSR
(calcium sensing receptors). Studies show that Cinacalcet Hydrochloride affects cell proliferation in CHO cells transfected with CaSRs. In addition, it is known that Cinacalcet Hydrochloride inhibits the secretion of the parathyroid hormone (PTH). These studies suggest that Cinacalcet Hydrochloride in instrumental in increasing the cytoplasmic concentration of Ca2+.
Furthermore, Cinacalcet Hydrochloride is an analog of NPS R-568 which contains a much better metabolic profile.
Function:
The use of secondary hyperparathyroidism for chronic renal disease is effective, and has good safety, tolerance and convenience and so on. It has been widely used in clinical.
Specification:
Identification |
IR/HPLC |
Solubility |
Slightly soluble in water, soluble in MeOH |
Melting point |
180-181°C |
Loss on drying |
≤0.5% |
Heavy metals |
≤20ppm |
Residue on ignition |
≤0.1% |
Related substance |
CF2H-Cinacalcet≤0.7% Any other impurity≤0.25% |
e.e.(HPLC) |
≥99.0% |
Purity(HPLC) |
≥99.0% |
The use of secondary hyperparathyroidism for chronic renal disease is effective, and has good safety, tolerance and convenience and so on. It has been widely used in clinical.
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