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80012-44-8 Cardiovascular Agents Pharmaceuticals
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Product name
Epinastine hydrochloride CAS:80012-44-8
Packaging, Storage &Shelf Life
Package
1kg/bag,25kg/ drum
Storage
Stored in original packaging for two years at a temperature not exceeding 40°C.
Shelf life
2 years if sealed and stored properly.
Specification
Test Item |
Analysis Specification |
Result |
Description |
White or almost white crystalline power Solubility: Meets the requirements |
white crystalline power Conforms
|
Identification Characteristic reaction for Cl- ion |
Its aqueous solution produces positive reaction of chlorides |
Positive reaction |
IR |
IR the spectrum is concordant with the spectrum of Epinastine hydrochloride RS |
Conforms |
UV |
Appears absorption maximum at 252nm |
Conforms |
pH |
3.0~5.5 |
4.5 |
Cyanide |
Meets the requirements |
Conforms |
Loss on drying |
Not more than 1.0% |
0.4% |
Residue on ignition |
Not more than 0.1% |
Conforms |
Heavy metals |
Not more than 20ppm |
<20ppm |
Related Substances Maximum Single impurity Total impurities |
Not more than 0.1% Not more than 1.0% |
0.05% 0.1% |
Assay(Dry Basis) |
Not less than 98.5%. |
99.7% |
Residual solvents Dichloromethane Ethanol Ethylacetate |
Not more than 500ppm Not more than 3000ppm Not more than 5000ppm |
Conforms Conforms\ Conforms |
Conclusion |
Conforms of Standard. |
Application
Epilepsin hydrochloride has a wide range of indications. It is not only suitable for allergic skin allergic reactions, but also has a good therapeutic effect on allergic bronchial asthma and allergic rhinitis. Epicin drugs have a high selectivity and specific affinity for H1 receptors. Under the interaction of multiple mechanisms, they can quickly and thoroughly eliminate allergic conditions, and there are no adverse conditions such as lethargy. Anti-allergic effects are more traditional than traditional drugs. Be strong.
Pharmacological action
Epilepsin hydrochloride is a histamine H1 receptor antagonist. This product has an inhibitory effect on histamine, leukotriene C4, PAF and serotonin, and can inhibit the release of histamine and slow reaction substance A (SRS-A) chemical medium. Due to the chemical structure of this product, this product is difficult to pass the blood-brain barrier, and the H1 receptor antagonism of the central nervous system is weak.
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