CasNo.477600-75-2,Tofacitinib with best price,(477600-75-2) Suppliers

1 Gram	FOB Price:USD 40.0000 -50.0000

Min.Order :1 Gram
Purity: 98%
Payment Terms : L/C,D/A,D/P,T/T,,MoneyGram

Keywords

477600-75-2 Antineoplastic Agents Pharmaceuticals

Quick Details

Appearance: white powder
Application:Auxiliaries and Other Medicinal Chemicals
PackAge: according to customers' requirements
ProductionCapacity:100|Kilogram|Month
Storage: 2 years
Transportation:International express delivery

Superiority:

About us

Our company has been in existence for 10 years since its establishment. We have our own unique team. The company integrates independent research and development, production and sales. We have established famous brands at home and abroad. At present, our customers have spread all over the world, we have rich Transportation experience, we aim to serve customers, to help customers, solve problems for customers. Look forward to working with you!

Details:

Product name

Tofacitinib CAS:477600-75-2

Packaging, Storage &Shelf Life

Package

1kg/bag,25kg/ drum

Storage

Stored in original packaging for two years at a temperature not exceeding 40°C.
Shelf life

2 years if sealed and stored properly.

Specification

Item	Specification
Specific rotation	+39.5 to +41.5°
State of solution(transmittance)	Clear 98.0% min.
Chloride[cl]	0.020% max.
Ammonium [NH4]	0.02% max.
Sulfate[SO4]	0.020% max
Iron[Fe]	10ppm max.
Heavy metals [Pb]	10ppm max
Arsenic[As2O3]	1ppm max
Other amino acids	Chromatographically not detectable
Loss on drying	0.20% max.
Residue on ignition[sulfated]	0.10% max.
Assay	99.0% min

Function

It is an inhibitor of the enzyme janus kinase 1 (JAK1) and janus kinase 3 (JAK 3) , which means that it interferes with the JAK-STAT signaling pathway, which transmits extracellular information into the cell nucleus, influencingDNA transcription.

In a mouse model of established arthritis, tofacitinib rapidly improved disease by inhibiting the production of inflammatory mediators and suppressing STAT1-dependent genes in joint tissue. This efficacy in this disease model correlated with the inhibition of both JAK1 and 3 signaling pathways, suggesting that tofacitinib may exert therapeutic benefit via pathways that are not exclusive to inhibition of JAK3.

Application

New oral drugs for the occasional method, (tofacitinib the introduction) to selectively inhibit JAK3 signal transduction pathways in cells, inhibition of CD4 T cell proliferation, further blocking interleukin (IL) 17, a gamma interferon, IL - 6, IL - 8 synthesis and secretion of cytokines, such as inhibition of patients with RA synovial fibroblasts proliferation and damaged cartilage further damage.Jak kinase inhibitors, the treatment of rheumatoid arth.

All Key Manufacturers and Suppliers of Baoji Guokang have routine inspections to ensure they are in compliance with the standards set in place during the original Supplier Assessment Inspection.

Production Inspection Process:

Our Group service includes regular and thorough inspections throughout the manufacturing process, eliminating the need to employ additional quality control inspectors.

- Raw material before any production begins

- Pre-production samples to ensure specifications are being met

- In-process to confirm that standards are maintained

- Pre-shipping to ensure that the product arrives to the customer exactly as expected and is packaged

correctly to prevent any damage in transit.

We can help operating split shipments, meeting the factory minimum quantity but ship them in 2 or 3 shipments with required gaps among. This allows you to move stock through your business without taking up space and capital.

We will arrange the subsequent shipments from our factory to your warehouse.

We can consolidate your small orders from multiple factories, delivering all at the same time to you or your customers,using the most cost-effective route available. At the time of order placement, we will offer details to you about the volume of each component part and what size container will be used.

We can offer the complete package from concept to delivery; arranging everything up until products arrive at your own door or distribution hub.

Delivery can be offered.

- Utilizing your own freight-forwarder

- FOB to a port in China

- CIF to a port near you

Whether you have your own freight-forwarder or you would like to organize shipment; whether you require delivery FOB in China or CIF to a port near you, we are glad to quote and supply whichever way you choose. Please feel free to discuss all options with us.