58-14-0 Pharmaceutical Raw Intermediates Pharmaceuticals
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Product name
Pyrimethamine CAS:58-14-0
Packaging, Storage &Shelf Life
Package
1kg/bag,25kg/ drum
Storage
Stored in original packaging for two years at a temperature not exceeding 40°C.
Shelf life
2 years if sealed and stored properly.
Specification
SPECIFICATION |
STANDARD |
RESULTS |
Appearance |
White or off white powder |
Complies |
Identification |
Positive |
Complies |
Clarity and Colour of Solution |
2.5%W/V mixed solution is clear; Colour ≤ BY6 |
Complies |
Acidity and Alkalinity |
Requires 0.01M sodium hydroxide VS not more than 0.2ml and 0.01M hydrochloric acid VS not more than 0.4ml. |
Complies |
Related Substance |
Any second spot in solution 1.0% w/v is not more than 0.25% |
Complies |
Sulphate |
80ppmmax |
≤ 80ppm |
Melting Point |
238 - 242 ℃ |
238-242℃ |
Loss on Drying |
0.50%max |
0.15% |
ASH |
0.10%max |
0.05% |
Assay(On Dry Basis) |
99.0 – 101.0% |
99.5% |
Conclusion |
UPTO STANDARD OF BP2014 USP35 |
Applications:
Because of its unique characteristics, Pyrimethamine can inhibit dihydrofolate reductase of Plasmodium, the parasite and thus interfere with the normal generation of radio folic acid, for Plasmodium falciparum and P. vivax erythrocyte pre-effective and commonly used for the cause of preventive medicine. In addition, it can inhibit the development of malaria parasites in mosquitoes, it can interrupt transmission. For the prevention of malaria and telogen anti-retroviral therapy clinic.
Usage:
Pyrimethamine is commonly used as an antimalarial drug(for both treatment and prevention), and is also used in the treatment of Toxoplasma.
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