134678-17-4 Lamivudine GMP Tenofovir Disoproxil Fumarate in China

Min.Order / FOB Price:Get Latest Price

1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 98.0%~102.0% (on anhydrous basis)
Payment Terms : L/C,D/A,D/P,T/T,,MoneyGram,Other

Keywords

134678-17-4 Lamivudine GMP Tenofovir Disoproxil Fumarate TDF in China 134678-17-4

Quick Details

Appearance:White to off-white crystalline powder
Application:HIV, HBV
PackAge:Two-layer LDPE bag and All Paper Drum
ProductionCapacity:200|Metric Ton|Year
Storage:2~8°C.
Transportation:as per request

Superiority:

134678-17-4 Lamivudine GMP

Tenofovir Disoproxil Fumarate

in China

LONZEAL Pharmaceuticals was founded in 2006 and has become a leading manufacturing company covering finished formulation, active pharmaceutical ingredients and advanced intermediates, where ICH guidelines have been strictly applied in the whole chain of R&D, manufacturing process and quality management.

LONZEAL is taking attentiveness and profession to build high quality products, and contributing to health and beautiful life for everyone in the world. The products and manufacturing site of Lonzeal have been approved and inspected by stringent drug authorities such as USFDA, WHO, China NMPA, Brazil ANVISIA and India DCGI, based on which, we have been supplying to esteemed customers globally in the past 15 years with regulatory compliance and good quality.

Our advantage:

1. Deeply cultivated in chemical foreign trade for many years, rich industry exporter experience in China

2. Direct sales by chemical raw material manufacturers, low prices

3.Excellent scientific research team to ensure product quality and purity

4.Processing and production in large factories, realizing fast shipment

Details:

composition

This product is mainly composed of tenofovir disoproxil fumarate, and its chemical name is :9-[(R)-2-[[[(isopropoxycarbonyl) oxy] methoxy] oxyphosphine] methoxy] -propyl] adenine fumarate (1∶1).

Chemical structural formula

Molecular formula: C19H30N5O10P C4H4O4

Molecular weight: 635.52

specifications

Tenofovir disoproxil fumarate is a tablet containing 300mg of tenofovir disoproxil fumarate (equivalent to 245mg of tenofovir disoproxil fumarate) per tablet. This specification can only be used for anti-HIV therapy.

indications

Tenofovir disoproxil fumarate is used in combination with other antiretroviral drugs to treat HIV-1 infection.

Additional important information regarding the use of tenofovir disoproxil fumarate for HIV-1 infection: Tenofovir disoproxil fumarate should not be used in combination with TRUVADA or ATRIPLA.

Pharmacological effects

This product is a nucleotide reverse transcriptase inhibitor that inhibits reverse transcriptase in a manner similar to nucleoside reverse transcriptase inhibitors and thus has potential anti-HIV-1 activity. The active ingredient, tenofovir bisphosphate, inhibits viral polymerases by directly and competitively binding to natural deoxyribose substrates and terminates DNA strands by insertion into DNA. In vitro, it is effective against a variety of viruses, including those resistant to nucleoside reverse transcriptase inhibitors. In vitro, IC50 was 1.6 micromol for wild type HIV-1, 4.9 micromol for HIV-2, and 1.1 micromol for HBV.

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