with immediately de...

with immediately deliveryParoxetine 110429-35-1 in stockfactory GMP

with immediately deliveryParoxetine 110429-35-1 in stockfactory GMP

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 98.5%-102.0%
  • Payment Terms : L/C,D/A,D/P,T/T,Other

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Paroxetine 110429-35-1 with immediately delivery Paroxetine 110429-35-1 in stock factory GMP Paroxetine 110429-35-1

Quick Details

  • Appearance:White or almost white solid
  • Application:Anti-Depression
  • PackAge:Two-layer LDPE bag and All Paper Drum
  • ProductionCapacity:50|Metric Ton|Year
  • Storage:Below 30℃
  • Transportation:as per request

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with immediately deliveryParoxetine 110429-35-1 in stockfactory GMP

Quality:

1. Customer Satisfaction is our priority and guarantee for the future.
2. We co-develop products and projects with our partners.
3.Place of Origin China with Super quality by reasonable price.
4.When you meet problems in mineral processing, we can provide technical guidance.
5.We will ship the goods that you order from us by EMS, DHL, UPS, or FedEx.We will decided to choose which courier depend on Different countries.To find the best way to delivery the goods for you.
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Superiority:
1. Quality: High purity, strict quality control, 10 years experience in chemical industry.
2. Price: Moderate price, more QTY more discount.
3. MOQ: Sample order is welcome to test quality.
4. Shipping time: In Stock, can be shipped in 2-3 days after payment confirmed.
5. Package: Professional packing or packed as request.
6. Service: Good after sale service,if any quality problems, we will support resending.
7. Payment term: ;T/T;Money Gram,Paypal，L/C

Details:

Paroxetine(1μMand10μM)distinctlyrestrainsTcellmigrationinducedbyCX3CL1throughinhibitingGRK2.ParoxetineinhibitsGRK2inducedactivationofERK.Paroxetine(10μM)reducespro-inflammatorycytokinesinLPS-stimulatedBV2cells.Paroxetine(0-5μM)leadstoadose-dependentinhibitiononLPS-inducedproductionofTNF-αandIL-1βinBV2cells.Paroxetinealsoinhibitslipopolysaccharide(LPS)inducednitricoxide(NO)productionandinduciblenitricoxidesynthase(iNOS)expressioninBV2cells.Paroxetine(5μM)blocksLPSinducedJNKactivationandattenuatesbaselineERK1/2activityinBV2cells.Paroxetinerelievesmicroglia-mediatedneurotoxicity,andsuppressesLPS-stimulatedpro-inflammatorycytokinesandNOinprimarymicroglialcells.

ParoxetinetreatmentobviouslyattenuatesthesymptomsofCIArats.ParoxetinetreatmentclearlypreventsthehistologicaldamageofjointsandalleviatesTcellsinfiltrationintosynovialtissue.ParoxetinerevealsastrongeffectoninhibitingCX3CL1productioninsynovialtissues.Paroxetine(20mg/kg/day)reducesthemyocytecrosssectionalareainratandROSformationintheremotemyocardium.Paroxetinereducesthesusceptibilitytoventriculartachycardia.ParoxetinetreatmentfollowingMIdecreasesLVremodelingandsusceptibilitytoarrhythmias,probablybyreducingROSformation.InCCIparoxetine-treatedgroup,paroxetine(10mg/kg,i.p.)produceshyperalgesiaatdays7and10(P<0.01),butadecreaseinpainbehaviorisseenatday14.Moreover,paroxetine(10mg/kg)significantlyattenuatestactilehypersensitivitywhencomparedtoCCIvehicle-treatedgroup.

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