Dalcetrapib(JTT-705;RO4607381)/ supplier with competitive price in stock-Rechems

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Dalcetrapib (JTT-705; RO-4607381) is a rhCETP inhibitor with IC50 of 0.2 μM that increases the plasma HDL cholesterol.IC50 value: 0.2 uM Target: CETP in vitro: Dalcetrapib modulates CETP activity.Dalcetrapib induces a conformational change in CETP, when added to human plasma.CETP-induced pre-β-HDL formation in human plasma is unchanged by Dalcetrapib ≤3 μM and increased at 10 μM.Dalcetrapib statistically and significantly increases pre-β-HDL formation .Dalcetrapib achieves 50% inhibition of CETP activity in human plasma at a concentration of 9 μM .Dalcetrapib inhibits the CETP activity of media in HepG2 in a dose-dependent manner .in vivo: Treatment with Dalcetrapib leads to significant increases in HDL-C levels.In hamsters injected with [3H]cholesterol-labeled autologous macrophages Dalcetrapib significantly increases fecal elimination of both [3H]neutral sterols and [3H]bile acids.Dalcetrapib increases plasma HDL-[3H]cholesterol .Dalcetrapib has 95% inhibition of CETP activity in male Japanese white rabbits at an oral dose of 30 mg/kg.Dalcetrapib increases the plasma HDL cholesterol level by 27% and 54%, respectively, when given at oral doses of 30 mg/kg or 100 mg/kg once a day for 3 days to male Japanese white rabbits .
Shanghai Rechem science Co., Ltd.
Rechemsis focus on R&D of new APIS, signal transduction inhibitors and pharmaceutical intermediates. We follow closely the industry trend, and the latest research achievements in life science area.
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