Propitocaine hydrochloride Chemical Properties
Melting point 168-170°C
storage temp. Refrigerator
solubility Freely soluble in water and in ethanol (96 per cent), very slightly soluble in acetone
form neat
Merck 14,7743
InChIKey BJPJNTKRKALCPP-UHFFFAOYSA-N
CAS DataBase Reference 1786-81-8(CAS DataBase Reference)
Safety Information
WGK Germany 3
RTECS UG5775000
HS Code 29242990
MSDS Information
Propitocaine hydrochloride Usage And Synthesis
Chemical Properties White Solid
Uses antibacterial
Uses Propitocaine hydrochloride is a local anesthetic of the amino amide type,it is often used in dentistry. Prilocaine is also often combined with lidocaine as a preparation for dermal anesthesia (lidocaine/pril ocaine or EMLA), for treatment of conditions like paresthesia.
Uses Anesthetic (local).
Definition ChEBI: The monohydrochloride salt of prilocaine.
Brand name Citanest (AstraZeneca).
Biological Functions Prilocaine hydrochloride (Citanest) is an amide anesthetic whose onset of action is slightly longer than that of lidocaine; its duration of action is comparable. Prilocaine is 40% less toxic acutely than lidocaine, making it especially suitable for regional anesthetic techniques. It is metabolized by the liver to orthotoluidine, which when it accumulates, can cause conversion of hemoglobin (HB+++ to methemoglobin (HB+++. Oxygen transport is impaired in the presence of methemoglobinemia. Treatment involves the use of reducing agents, such as methylene blue, given intravenously, to reconvert methemoglobin to hemoglobin.
Contact allergens Prilocaine in a local anesthetic of the amide group. It can induce allergic contact dermatitis, particularly from EMLA cream.