Cycloastragenol

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Cycloastragenol Overview

Cycloastragenol (CAG) also known as T-65 is a natural tetracyclic triterpenoid obtained from the Astragalus membranaceus plant. It was first discovered when Astragalus membranaceus extract was being evaluated for its active ingredients with anti-aging properties.

Cycloastragenol can also be derived from Astragaloside IV via hydrolysis action. Astragaloside IV is the major active ingredient in Astragalus membranaceus herb.  Although Cycloastragenol and Astragaloside IV are similar in their chemical structure, cycloastragenol is lighter in molecular weight than Astragaloside IV. Consequently, Cycloastragenol is more efficient due to high bioavailability and thus high metabolism of cycloastragenol. The high metabolism of cycloastragenol is noted in the intestinal epithelial via passive diffusion.

The astragalus herb have been used as a Chinese traditional medicine for centuries and is also being used today. Astragalus plant has been used due to its beneficial effects including anti-bacterial, anti-inflammatory as well as ability to enhance immunity.

CAG is indicated as an anti-aging compound that boosts the activity of the enzyme telomerase and wound healing. It is currently the major compound known to induce telomerase in humans, thus a great prospect supplement for further development.

Cycloastragenol is identified as telomerase activator, that plays role of increasing the length of telomeres. Telomeres are protective caps composed of nucleotide repeats at the end of the chromosome. These telomeres become shorter after every cell division which results to cell senescence and degradation. Further, the telomeres could also be shortened by oxidative stress.

This extreme shortening of telomeres is associated with aging, death and some ag-related disorders. Fortunately, telomerase enzyme is able to increase the length of these telomeres.

Although there no extensive studies to prove the ability of cycloastragenol to extend lifespan, it is a promising anti-aging compound. It has been proved to eliminate the signs of aging including fine lines and wrinkles. CAG may also lower the threat of developing degenerative disorders such as Parkinson’s, Alzheimer’s, and cataracts.

Despite the many cycloastragenol health benefits, there are concerns that it could lead to cancer or accelerate cancer. However, some studies conducted with animal subjects report benefits of cycloastragenol without any incidence of cancer.

Cycloastragenol powder for sale is readily available online and can be purchased from the many well-known cycloastragenol suppliers.

Despite, the many cycloastragenol health benefits indicated, it is still a new member under studies. Furthermore, cycloastragenol side effects are not very clear, hence should be used with caution.

What is Cycloastragenol

Cycloastragenol

Cycloastragenol is a triterpenoid saponin compound derived from the root of Astragalus herb. Astragalus membranaceus plant has been used in Traditional Chinese medicine (TCM) for over 2000 years and still being used in herbal preparations.

The astragalus herb has been known for its ability to improve the immunity, protect the live, act as a diuretic as well as a possess other health properties such as anti-hypersensitivity, antibacterial, anti-aging and anti-stress benefits.

Cycloastragenol commonly known as TA-65 but has also been referred to as Cyclogalagenin, Cyclogalegenin, Cyclogalegigenin, and Astramembrangenin. Cycloastragenol supplement is largely known as anti-aging agent, however, other cycloastragenol health benefits include enhancing immune system, anti-inflammatory and anti-oxidative properties.

Cycloastragenol and Astragaloside IV

Both cycloastragenol and Astragaloside IV occur naturally in the astragalus plant extract.  Astragaloside IV is the primary active ingredient in astragalus membranaceus, however, occurs in minute quantities in the root. The process of extracting these saponins, cycloastragenol and astragaloside IV, is usually difficult due to the high level of purification required.

While both cycloastragenol and astragaloside IV are derived from astragalus herb, cycloastragenol can also be obtained from astragaloside IV through hydrolysis process.

These two compounds have a similar chemical structure, however, cycloastragenol is lighter in molecular weight than astragaloside IV and is also more bioavailable.

Benefits of Cycloastragenol

i.Cycloastragenol and immune system

Cycloastragenol can help improve the immunity through boosting the proliferation of T lymphocyte. The ability of cycloastragenol supplement to activate telomerase enables it to stimulate DNA repair while leading o growth and elongation of telomere.

ii.Cycloastragenol and Anti-aging

Cycloastragenol anti-aging properties are the main interest of most research today. CAG has been indicated to delay aging in humans as well as reduce signs of aging such as wrinkles and fine lines. Cycloastragenol anti-aging activity is achieved through four different mechanisms. The cycloastragenol anti-aging mechanisms include;

Fighting oxidative stress

Oxidative stress occurs naturally when there is an imbalance between free radicals and antioxidant in the body. If not controlled, oxidative stress can accelerate the aging process as well lead to chronic conditions such as cancer, cardiac disorder and diabetes.

Cycloastragenol astragalus extract is an excellent antioxidant compound and also improves the capacity of the naturally existing antioxidants. This helps delay aging and also prevent the occurrence of age-related disorders.