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Altrenogest is a progestogen structurally related to veterinary steroid trenbolone. Altrenogest is a synthetic trienic C21 steroidal progestomimetic, belonging to the 19-nor-testosterone series. It is an orally active (pro)gestagen. Like all steroids, altrenogest acts by its liposolubility by penetrating the target cells where it binds to specific receptors. In veterinary medicine, altrenogest is used in gilts and mares for zootechnical purposes (oestrus synchronization).
An in vitro yeast structure–activity relationships bioassay study found that altrenogest was the most potent agonist of both the progesterone receptor (PR) and the androgen receptor (AR) of a large selection of other progestogens as well as anabolic–androgenic steroids (AAS). The observed potency of altrenogest even exceeded that of metribolone (methyltrienolone, R-1881), which was the second most potent compound. In the study, it showed an EC50 of 0.64 nM for the AR and 688% of the relative activational potency of testosterone and an EC50 of 0.3 nM and 1,300% of the relative activational potency of progesterone, with an AR/PR activational potency ratio of 0.53.
Catalogue number: | PA 28 58000 |
Chemical name: | Altrenogest |
CAS Number: |
850-52-2 |
Category: | pharmaceutical standards,intermediates,fine chemicals,steroids |
Synonyms: |
(17β)-17-Hydroxy-17-(2-propen-1-yl)estra-4,9,11-trien-3-one; (17β)-17-Hydroxy-17-(2-propenyl)estra-4,9,11-trien-3-one; 17α-Allyl-17-hydroxyestra-4,9,11-trien-3-one; Allyltrenbolone; |
Molecular form: | C21H26O2 |
Appearance: | Light Yellow Solid |
Mol. Weight: | 310.43 |
Storage: | 2-8°C Controlled Substance, Refrigerator |
Shipping Conditions: | Ambient |
Applications: | NA |
BTM: | NA |
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