Pharmaceutical grade on hot selling 17α-estradiol 57-91-0 Good Supplier In China
Min.Order / FOB Price:Get Latest Price
| 0 Metric Ton |
Negotiable |
- Min.Order :0 Metric Ton
- Purity: 99%
- Payment Terms : L/C,D/A,D/P,T/T,
Keywords
57-91-0 Good Supplier In China 17α-estradiol on hot selling Pharmaceutical grade 17α-estradiol
Quick Details
- Appearance:white powder
- Application:Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a
- PackAge:According to client's requirements
- ProductionCapacity:1-1.5|Metric Ton|Year
- Storage:20kg in stock
- Transportation:According to client's requirements
Superiority:
α-Estradiol is an endogenous ligand for estrogen receptors ERα (Ki = 0.2 nM) and ERβ (Ki = 1.2 nM). Studies indicate that α-Estradiol is a short acting estrogen which only forms complexes with estrogen ligand receptors for a short period of time. These studies suggest that α-estradiol is beneficial in studying the affects caused by the MAPK signaling cascade such as cell division, neuronal differentiation, and neuronal survival in the developing brain. Furthermore, α-estradiol inhibits the influx of calcium in human aortic smooth muscle cells.
17alpha-estradiol is an estradiol that is estra-1,3,5(10)-triene substituted by hydroxy groups at positions 3 and 17 (the 17alpha stereoisomer). It is a 17alpha-hydroxy steroid, a 3-hydroxy steroid and an estradiol.
Details:
17α-Estradiol is the natural optical isomer of 17β-estradiol, the major estrogen secreted by the premenopausal ovary. 17α-Estradiol is a less active isomer than its counterpart, displaying 100-fold lower estrogenic activity relative to 17β-estradiol. It can inhibit 5α-reductase, which plays a role in regulating hair growth. 17α -estradiol is reported to activate the MAPK/ERK and PI3K-Akt signaling pathways via activation of the estrogen receptor-X and has been shown to be neuroprotective after an ischemic stroke and oxidative stress and in transgenic mice with Alzheimer’s disease.
| Catalogue Number | E887995 |
| Chemical Name | 17α-Estradiol |
| Synonyms | (17α)-Estra-1,3,5(10)-triene-3,17-diol; 1,3,5-Estratriene-3,17α-diol; 13β-Methyl-1,3,5(10)-gonatriene-3,17α-diol; 17-Epiestradiol; 17α-Oestradiol; 3,17-Dihydroxyestratriene; 3,17α-Dihydroxyoestra-1,3,5(10)-triene; Alfatradiol; Epiestrol; Estra-1,3,5(10)-triene-3,17α-diol; NSC 20293; α-Estradiol; Ethinyl Estradiol Impurity L (EP); Estradiol 17α-Hydroxy Impurity Estradiol EP Impurity B |
| Impurity | Estradiol 17-Hydroxy Impurity; Estradiol EP Impurity B; Ethinylestradiol EP Impurity L |
| CAS Number | 57-91-0 |
| Molecular Formula | C??H??O? |
| Appearance | White to Off-White Solid |
| Melting Point | 210-219°C |
| Molecular Weight | 272.38 |
| Storage | Refrigerator |
| Solubility | Dioxane (Slightly, Heated, Sonicated), Methanol (Slightly) |
| Category | Standards; Steroids; Pharmaceutical/API Drug Impurities/Metabolites; |
You Might Also Like
Related Searches
About|Contact|Cas|Product Name|Molecular|Country|Encyclopedia
Message|New Cas|MSDS|Service|Advertisement|CAS DataBase|Article Data|Manufacturers | Chemical Catalog
©2008 LookChem.com,License: ICP
NO.:Zhejiang16009103
complaints:service@lookchem.com Desktop View