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good supplierHigh Quality low price 1352226-88-0 AZD6738
good supplierHigh Quality low price 1352226-88-0 AZD6738
good supplierHigh Quality low price 1352226-88-0 AZD6738
good supplierHigh Quality low price 1352226-88-0 AZD6738
good supplierHigh Quality low price 1352226-88-0 AZD6738

good supplierHigh Quality low price 1352226-88-0 AZD6738

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10 Metric Ton

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  • Min.Order :10 Metric Ton
  • Purity: 97%
  • Payment Terms : L/C,T/T,Other

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1352226-88-0 good supplier High Quality 1352226-88-0 low price 1352226-88-0 AZD6738

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  • Appearance:Powder or liquid
  • Application:Medicinal Chemistry Biomedicine Pharmaceutical intermediates Chemistry experiment Biological experiments Chemical reagent For R&D use only.
  • PackAge:According to customer
  • ProductionCapacity:|Metric Ton|Day
  • Storage:Store in a tightly closed container, in a cool and dry place.
  • Transportation:Fedex,DHL,TNT,BY SEA and BY AIR

Superiority:

 Ceralasertib, also known as AZD6738, is an orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related (ATR) kinase, with potential antineoplastic activity. Upon oral administration, ATR kinase inhibitor Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1. This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation, disruption of DNA damage repair, and the induction of tumor cell apoptosis.
 
AZD 6738 is an orally bioavailable inhibitor of the serine/threonine protein kinase ataxia telangiectasia mutated (ATM) and Rad3-related (ATR; IC50 = 1 nM). It can inhibit ATR substrate Chk1 Ser345 phosphorylation in cells with an IC50 value of 74 nM. AZD 6738 has been shown to inhibit the proliferation of various solid and hematological cell lines with IC50 values of less than 1 µM and to reduce tumor growth in several ATM-deficient xenograft models. When used in combination with either DNA damaging chemotherapy agents or ionizing radiation, AZD 6738 demonstrated synergistic cell killing activity across multiple cell lines in vitro and in xenograft studies.
 

Details:

Ceralasertib, also known as AZD6738,is an orally available morpholino-pyrimidine-based inhibitor of ataxia telangiectasia and rad3 related(ATR) kinase,with potential antineoplastic activity.Upon oral administration,ATR kinase inhibitor Ceralasertib selectively inhibits ATR activity by blocking the downstream phosphorylation of the serine/threonine protein kinase CHK1.This prevents ATR-mediated signaling, and results in the inhibition of DNA damage checkpoint activation,disruption of DNA damage repair,and the induction of tumor cell apoptosis.

Alternate Name 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine;ceralasertib
Appearance White Solid
CAS # 1352226-88-0
Molecular Formula C??H??N?O?S
Molecular Weight 412.51
Purity ≥98% by HPLC
Solubility DMSO (~0.5 mg/ml)
SMILES CC1COCCN1C2=NC(=NC(=C2)C3(CC3)S(=N)(=O)C)C4=C5C=CNC5=NC=C4
InChi InChI=1S/C20H24N6O2S/c1-12-11-28-8-7-26(12)18-10-16(15-9-17(15)29(2,21)27)24-20(25-18)14-4-6-23-19-13(14)3-5-22-19/h3-6,10,12,15,17,21H,7-9,11H2,1-2H3,(H,22,23)/t12-,15?,17-,29-/m1/s1
InChi Key QCMVAPXCVDFKBD-UYKWCLKASA-N
PubChem CID 121228639
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.

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