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Fast Delivery 94497-51-5 ManufacturerHot Sale Tamibarotene
Fast Delivery 94497-51-5 ManufacturerHot Sale Tamibarotene
Fast Delivery 94497-51-5 ManufacturerHot Sale Tamibarotene
Fast Delivery 94497-51-5 ManufacturerHot Sale Tamibarotene
Fast Delivery 94497-51-5 ManufacturerHot Sale Tamibarotene

Fast Delivery 94497-51-5 ManufacturerHot Sale Tamibarotene

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10 Metric Ton

Negotiable

  • Min.Order :10 Metric Ton
  • Purity: 97%
  • Payment Terms : L/C,T/T,Other

Keywords

Fast Delivery 94497-51-5 94497-51-5 Manufacturer Hot Sale Tamibarotene

Quick Details

  • Appearance:Powder or liquid
  • Application:Medicinal Chemistry Biomedicine Pharmaceutical intermediates Chemistry experiment Biological experiments Chemical reagent For R&D use only.
  • PackAge:According to customer
  • ProductionCapacity:|Metric Ton|Day
  • Storage:Store in a tightly closed container, in a cool and dry place.
  • Transportation:Fedex,DHL,TNT,BY SEA and BY AIR

Superiority:

Tamibarotene is a retinoic acid receptor α (RARα) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. Exhibits antiproliferative effects against a variety of human tumor cells lines (mean values of 35, 40 and 60% growth inhibition at 0.1, 1 and 10 M respectively) and displays anticancer activity against acute promyelocytic leukemia in vivo. It has also been shown to suppress the growth of other myeloid and lymphoid malignant cells

Tamibarotene is an orally-active, synthetic retinoid, developed to overcome all-trans retinoic acid resistance, with potential antineoplastic activity. It is a retinoic acid receptor (RAR) agonist with high specificity for RARalpha and RARbeta over RARgamma that induces differentiation and apoptosis of HL-60 cells in vitro. It exhibits antiproliferative effects against a variety of human tumor cells lines and displays anticancer activity against acute promyelocytic leukemia in vivo. Temporarily and spatially specific expression of RARs suggests their pivotal roles in the adult brain. It is considered to be a promising candidate drug for treatment of Alzheimer's disease because of its transcriptional controls of multiple target genes involved in etiology and pathology of Alzheimer's disease.

Details:

AM 80 is a RARα (retinoic acid receptor α) agonist that induces differentiation (ED50 = 0.79 nM) and apoptosis of HL-60 cells in vitro. AM 80 displays anticancer activity against acute promyelocytic leukemia in vitro and exhibits antiproliferative effects against a variety of tumor cell lines. AM 80 is an activator of RAR β.

Catalogue Number T005800
Chemical Name Tamibarotene
CAS Number 94497-51-5
Molecular Formula C??H??NO?
Appearance Off-White Solid
Melting Point 228-230°C
Molecular Weight 351.44
Storage Refrigerator
Solubility DMSO, Methanol
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites;
Applications Synthetic retinoic acid receptor-α/β-selective retinoid. Antineoplastic.

 

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