389139-89-3 On Sale...

389139-89-3 On Sale exporterglobal Omadacycline
389139-89-3 On Sale exporterglobal Omadacycline
389139-89-3 On Sale exporterglobal Omadacycline
389139-89-3 On Sale exporterglobal Omadacycline
389139-89-3 On Sale exporterglobal Omadacycline

389139-89-3 On Sale exporterglobal Omadacycline

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10 Metric Ton

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  • Min.Order :10 Metric Ton
  • Purity: 97%
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389139-89-3 On Sale 389139-89-3 exporter global Omadacycline

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  • Appearance:Powder or liquid
  • Application:Medicinal Chemistry Biomedicine Pharmaceutical intermediates Chemistry experiment Biological experiments Chemical reagent For R&D use only.
  • PackAge:1038915-60-4 Wholesaler
  • ProductionCapacity:best quality 1038915-60-4|Metric Ton|Day
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Omadacycline is a new tetracycline antibiotic in the pipeline, which can inhibit the 30s subunit of bacterial ribosome.
 
Omadacycline, also known as PTK 0796 and Amadacyclin, is a novel first-in-class aminomethylcycline with potent activity against important skin and pneumonia pathogens, including community-acquired methicillin-resistant Staphylococcus aureus (MRSA), β-hemolytic streptococci, penicillin-resistant Streptococcus pneumoniae, Haemophilus influenzae, and Legionella. Omadacycline is active against strains expressing the two main forms of tetracycline resistance (efflux and ribosomal protection). The primary effect of omadacycline is on bacterial protein synthesis, inhibiting protein synthesis with a potency greater than that of tetracycline. The binding site for omadacycline is similar to that for tetracycline.

Details:

Omadacycline is an aminomethylcycline antibiotic. It is active against tetracycline-susceptible and -resistant strains of S. aureus, E. faecalis, E. faecium, S. pneumoniae, and E. coli, as well as β-hemolytic streptococci (MICs = ≤0.06-2 µg/ml). Omadacycline increases survival in mouse models of systemic infection with tetracycline-sensitive and -resistant strains of S. pneumoniae, S. aureus, or E. coli (ED50s = 0.3-3.34 mg/kg). Formulations containing omadacycline have been used in the treatment of community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections

Catalogue Number O633020
Chemical Name Omadacycline
Synonyms (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-9-[[(2,2-dimethylpropyl)amino]methyl]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; Amadacycline; BAY 73-7388; MK 2764; PTK 0796;
CAS Number 389139-89-3
Molecular Formula C??H??N?O?
Molecular Weight 556.65
Category Standards; Pharmaceutical/API Drug Impurities/Metabolites; Antibotics;
Applications Omadacycline is a potent an demonstrates efficacy against both Bacillus anthracis and Yersinia pestis; Also, it is a novel aminomethylcycline antibiotic in clinical development for community-acquired bacterial pneumonia (CABP).

 

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