best quality 431898...

best quality 431898-65-6 PS-1145 Wholesaler
best quality 431898-65-6 PS-1145 Wholesaler
best quality 431898-65-6 PS-1145 Wholesaler
best quality 431898-65-6 PS-1145 Wholesaler
best quality 431898-65-6 PS-1145 Wholesaler

best quality 431898-65-6 PS-1145 Wholesaler

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431898-65-6 PS-1145 best quality 431898-65-6 431898-65-6 Wholesaler

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  • Appearance:Powder or liquid
  • Application:Medicinal Chemistry Biomedicine Pharmaceutical intermediates Chemistry experiment Biological experiments Chemical reagent For R&D use only.
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IKK Inhibitor X is a cell-permeable β-carboline compound that exhibits anti-inflammatory properties. A potent, ATP-competitive, and reversible inhibitor of IKK.

Alternate Name N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)nicotinamide
Appearance Yellow solid
CAS # 431898-65-6
Molecular Formula C??H??ClN?O
Molecular Weight 322.75
Purity ≥98% by HPLC
Solubility DMSO (>5 mg/ml)
SMILES C1=CC(=CN=C1)C(=O)NC2=C3C(=CC(=C2)Cl)C4=C(N3)C=NC=C4
InChi InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23)
InChi Key JZRMBDHPALEPDM-UHFFFAOYSA-N
PubChem CID 9949093
MDL Number MFCD08705411
Handling Protect from air and light
Storage Conditions -20°C
Shipping Conditions Gel Pack
USAGE For Research Use Only! Not For Use in Humans.
 

Details:

Nuclear factor-κB (NF-κB) is a protein complex which modulates gene transcription relevant to cellular responses to inflammation, stress, infection, and other factors.1 The inhibitor of NF-κB kinase β (IKKβ), in complex with IKKα and IKKγ, phosphorylates inhibitor of NF-κB A and B (IκA and IκB) and other proteins involved in NF-κB signaling, and thus plays a central regulatory role.1 PS-1145 is a potent inhibitor of IKKβ (IC50 = 88-100 nM).Through this action, it is used to elucidate roles for NF-κB both in cells and in vivo.

 
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