CasNo.1225497-78-8,good supplier 1225497-78-8 in stock High Quality ON 01910 sodiuM salt,(1225497-78-8) Suppliers

10 Metric Ton	Negotiable

Min.Order :10 Metric Ton
Purity: 97%
Payment Terms : L/C,T/T,Other

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1225497-78-8 in stock 1225497-78-8 good supplier High Quality ON 01910 sodiuM salt

Quick Details

Appearance:Powder or liquid
Application:Medicinal Chemistry Biomedicine Pharmaceutical intermediates Chemistry experiment Biological experiments Chemical reagent For R&D use only.
PackAge:According to customer
ProductionCapacity:|Metric Ton|Day
Storage:Store in a tightly closed container, in a cool and dry place.
Transportation:Fedex,DHL,TNT,BY SEA and BY AIR

Superiority:

Rigosertib (ON-01910 sodium salt) is a synthetic benzyl styryl sulfone analogue with potential antineoplastic activity. Polo-like kinase 1 inhibitor ON 01910.Na inhibits polo-like kinase1 (Plk1), inducing selective G2/M arrest followed by apoptosis in a variety of tumor cells while causing reversible cell arrest at the G1 and G2 stage without apoptosis in normal cells. This agent may exhibit synergistic antitumor activity in combination with other chemotherapeutic agents. Plk1, named after the polo gene of Drosophila melanogaster, is a serine/threonine protein kinase involved in regulating mitotic spindle function in a non-ATP competitive manner. Note: this product is supplied as sodium salt.

Chemical Formula:	C₅₀H₆₆Cl₄N₈O₁₀S₂
Molecular Weight:	1145.05
Synonyms:	Tenapanor; Rovatirelin Hydrate; Tenapanor(free base)
MDL No.:	MFCD28386333
EINECS / EC No.:	N/A
Pubchem CID:	71587953
IUPAC Name:	1-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethyl]-3-[4-[2-[2-[2-[[3-[(4S)-6,8-dichloro-2-methyl-3,4-dihydro-1H-isoquinolin-4-yl]phenyl]sulfonylamino]ethoxy]ethoxy]ethylcarbamoylamino]butyl]urea
Standard InchI:	InChI=1S/C50H66Cl4N8O10S2/c1-61-31-43(41-27-37(51)29-47(53)45(41)33-61)35-7-5-9-39(25-35)73(65,66)59-15-19-71-23-21-69-17-13-57-49(63)55-11-3-4-12-56-50(64)58-14-18-70-22-24-72-20-16-60-74(67,68)40-10-6-8-36(26-40)44-32-62(2)34-46-42(44)28-38(52)30-48(46)54/h5-10,25-30,43-44,59-60H,3-4,11-24,31-34H2,1-2H3,(H2,55,57,63)(H2,56,58,64)/t43-,44-/m0/s1
InchI Key:	DNHPDWGIXIMXSA-CXNSMIOJSA-N
SMILES:	CN1CC(C2=C(C1)C(=CC(=C2)Cl)Cl)C3=CC(=CC=C3)S(=O)(=O)NCCOCCOCCNC(=O)NCCCCNC(=O)NCCOCCOCCNS(=O)(=O)C4=CC=CC(=C4)C5CN(CC6=C5C=C(C=C6Cl)Cl)C
Appearance:	-
Melting Point:	N/A
Boiling Point:	N/A
Density (Theoretical):	N/A

Details:

ON-01910 is a potent, non-ATP-competitive inhibitor of polo-like kinase 1 (Plk1; IC₅₀ = 9 nM), a serine/threonine protein kinase involved in the regulation of cell cycling. It induces apoptosis in a wide array of tumor cell lines (GI₅₀ = 50-200 nM) and blocks the growth of multidrug resistant cancer cell lines.ON-01910 is active in vivo when administered intraperitoneally and synergizes with chemotherapeutic agents, preventing tumor growth or abolishing tumors in human xenograft nude mouse models