Paromomycin sulfate cas 1263-89-4 Paromomycin sulfate salt
Paromomycin sulfate salt API 1263-89-4 professional supplier
Specification:
Name: Paromomycin Sulfate
Molecular Formula: C23H45N5O14.H2SO4
Molecular Weight: 713.71
CAS: 1263-89-4
EINECS: 215-031-7
Standard: USP32
assay no less than 99%
White or almost white crystalline powder; none stink, assay no less than 99%.
English name:paromomycin sulfate Molecular Formula:C23H47N5O18S Molecular Weight:713.707 CAS Registry Number:1263-89-4 EINECS:215-031-7
Quality:CP/USP
Boiling point:1059.2°C at 760 mmHg Flash point:594.4°C Vapour Pressur:0mmHg at 25°C Appearance:White or light yellow powder. Application:Is aminoglycoside antibiotics, and can be used in the treatment of bacterial dysentery and other gastrointestinal bacteria infection, is the treatment amebic dysentery specifics.
Description |
An oligosaccharide antibiotic produced by various streptomyces. [PubChem] |
Categories |
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CAS number | 1263-89-4 |
Weight | Average: 615.6285 Monoisotopic: 615.296301173 |
Chemical Formula | C23H45N5O14 |
InChI Key | InChIKey=UOZODPSAJZTQNH-LSWIJEOBSA-N |
Indication | For the treatment of acute and chronic intestinal amebiasis (it is not effective in extraintestinal amebiasis). Also for the management of hepatic coma as adjunctive therapy. |
Pharmacodynamics | Paromomycin is a broad spectrum aminoglycoside antibiotic produced by Streptomyces rimosus var. paromomycinus. The in vitro and in vivo antibacterial action of paromomycin closely parallels that of neomycin. |
Mechanism of action | Paromomycin inhibits protein synthesis by binding to 16S ribosomal RNA. Bacterial proteins are synthesized by ribosomal RNA complexes which are composed of 2 subunits, a large subunit (50s) and small (30s) subunit, which forms a 70s ribosomal subunit. tRNA binds to the top of this ribosomal structure. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced. Continuous production of defective proteins eventually leads to bacterial death. |
Absorption | Poorly absorbed after oral administration, with almost 100% of the drug recoverable in the stool. |
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