supplier factory 2226735-55-1 GSK-547 Good Supplier In China

supplier factory 2226735-55-1 GSK-547 Good Supplier In China

Min.Order / FOB Price:Get Latest Price

10 Metric Ton	Negotiable

10 Metric Ton

Negotiable

Min.Order :10 Metric Ton
Purity: 97%
Payment Terms : L/C,T/T,,Other

Keywords

supplier 2226735-55-1 factory 2226735-55-1 GSK-547 2226735-55-1 Good Supplier In China

Quick Details

Appearance:Powder or liquid
Application:Medicinal Chemistry Biomedicine Pharmaceutical intermediates Chemistry experiment Biological experiments Chemical reagent For R&D use only.
PackAge:According to customer
ProductionCapacity:|Metric Ton|Day
Storage:Store in a tightly closed container, in a cool and dry place.
Transportation:Fedex,DHL,TNT,BY SEA and BY AIR

Superiority:

GSK547 is a highly selective and potent RIP1 (RIPK1) inhibitor which displays 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK963.

GSK547 (RIP1i, GSK 547) is a highly selective and potent inhibitor of RIP1 kinase that robustly targets RIP1 in vivo; exhibited a 400-fold improvement in mouse pharmacokinetic oral exposure compared with GSK'963; reprogrammed TAMs toward an MHCIIhiTNFα+IFNγ+ immunogenic phenotype in a STAT1-dependent manner. RIP1 inhibition in TAMs resulted in cytotoxic T cell activation and T helper cell differentiation toward a mixed Th1/Th17 phenotype, leading to tumor immunity in mice and in organotypic models of human Pancreatic ductal adenocarcinoma (PDA).

Details:

GSK547 (GSK-547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1), inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer.

Medchemexpress, HY-114492 5mg GSK547 CAS:2226735-55-1 GSK547 (GSK'547) is a highly selective and potent inhibitor of receptor-interacting serine/threonine protein kinase 1 (RIP1) , inhibits macrophage-mediated adaptive immune tolerance in pancreatic cancer [1] . Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.

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