Hot Sale High Purity 1234423-95-0Tenapanor in bulk supply

Hot Sale High Purity 1234423-95-0Tenapanor in bulk supply

Min.Order / FOB Price:Get Latest Price

10 Metric Ton	Negotiable

10 Metric Ton

Negotiable

Min.Order :10 Metric Ton
Purity: 97%
Payment Terms : L/C,T/T,,Other

Keywords

Hot Sale 1234423-95-0 High Purity 1234423-95-0 Tenapanor in bulk supply

Quick Details

Appearance:Powder or liquid
Application:Medicinal Chemistry Biomedicine Pharmaceutical intermediates Chemistry experiment Biological experiments Chemical reagent For R&D use only.
PackAge:According to customer
ProductionCapacity:|Metric Ton|Day
Storage:Store in a tightly closed container, in a cool and dry place.
Transportation:Fedex,DHL,TNT,BY SEA and BY AIR

Superiority:

This active molecular is an sodium-proton exchanger NHE3 inhibitor under the development of Ardelyx. This antiporter protein plays a really important role in sodium handling in the gastrointestinal tract and kidney and it regulates the levels of sodium absorbed and secreted by the body. Therefore, tenapanor can be useful in the treatment of chronic kidney disease and hypertension because both of them are exacerbated by excess sodium in the diet. In Oct 2016, Phase-III clinical trials in Hyperphosphataemia (in patients with end-stage renal disease) in USA was on going.

Tenapanor, also known as AZD-1722 and RDX 5791, is an inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3, which plays a prominent role in sodium handling in the gastrointestinal tract and kidney. Tenapanor possesses an excellent preclinical safety profile and, as of now, there are no serious concerns about its side effects.

Details:

Tenapanor is an inhibitor of the sodium-proton exchanger NHE3. This antiporter protein is found in the kidney and intestines, and normally acts to regulate the levels of sodium absorbed and secreted by the body. When administered orally, tenapanor selectively inhibits sodium uptake in the intestines, limiting the amount absorbed from food, and thereby reduces levels of sodium in the body. This may make it useful in the treatment of chronic kidney disease and hypertension, both of which are exacerbated by excess sodium in the diet.