1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acidCAS NO.:53-86-1

Min.Order / FOB Price:Get Latest Price

1 Gram	FOB Price: USD 2.0000

1 Gram

FOB Price: USD 2.0000

Min.Order :1 Gram
Purity: 0.99
Payment Terms : L/C,D/A,D/P,T/T,,MoneyGram,Other

Keywords

1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-ylacetic acid N-(4-Chlorobenzoyl)-4-Methoxyphenyl-Hydrazine N-p-Chlorbenzoyl-5-methoxy-2-methylindole-3-acetic acid

Quick Details

Appearance:white powder
Application:Pharmaceutical intermediates
PackAge:bag
ProductionCapacity:10000|Gram|Day
Storage:Room temperature
Transportation:By Sea/Air/DHL

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Clinical Use

Indomethacin is available for the short-term treatment of acute gouty arthritis, acute pain of ankylosing spondylitis, and osteoarthritis. An injectable form to be reconstituted also is available as the sodium trihydrate salt for IV use in premature infants with patent ductus arteriosus. Because of its ability to suppress uterine activity by inhibiting prostaglandin biosynthesis, indomethacin also has an unlabeled use to prevent premature labor.

Side effects

All of these drugs produce analgesic effects, antipyresis, and antiinflammatory effects.Due to the high incidence of gastric irritation, headache, nausea, and other side effects, including hematological effects and coronary vasoconstriction, they are not useful as an initial treatment for pain. GI irritation and ulceration occur to a lesser extent with etodolac. Indomethacin is useful in the treatment of acute gout, osteoarthritis, ankylosing spondylitis, and acceleration of the closure of the ductus arteriosus in premature infants. The tocolytic effects of indomethacin to prevent preterm labor are the result of its effects on prostaglandin synthesis. However, the toxicity of the drug limits such application, since it increases fetal morbidity. Indomethacin is contraindicated in pregnancy, in asthmatics, and in those with gastric ulcers or other ulceration of the GI tract. Indomethacin may increase the symptoms associated with depression or other psychiatric disturbances and those associated with epilepsy and Parkinson’s disease. The drug should be used with caution in such patients.

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