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1092364-38-9 1092364-38-9 Poziotinib (Synonyms: HM781-36B; NOV120101) Low price high purity 1092364-38-9 Poziotinib (Synonyms: HM781-36B; NOV120101)
Low price high purity 1092364-38-9 Poziotinib (Synonyms: HM781-36B; NOV120101) in stock
Poziotinib (HM781-36B) is an orally active, irreversible pan-HER inhibitor, which effectively inhibits EGFRwt, HER-2 and HER-4 with IC50s of 3.2, 5.3 and 23.5 nM, respectively. Poziotinib (HM781-36B) also shows excellent inhibitory activities against mutated EGFRs, including EGFRT790M and EGFRL858R/T790M, with IC50s of 4.2 and 2.2 nM, respectively. Excellent antitumor activity[1][2].
Molecular Weight |
491.34 |
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Formula |
C??H??Cl?FN?O? |
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CAS No. |
1092364-38-9 |
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SMILES |
C=CC(N1CCC(OC2=CC3=C(NC4=CC=C(Cl)C(Cl)=C4F)N=CN=C3C=C2OC)CC1)=O |
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Shipping |
Room temperature in continental US; may vary elsewhere. |
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Storage |
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