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Albendazole 54965-21-8 Albendazole 54965-21-8 supplier Albendazole price
Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms. It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Albendazole (0.05% in the diet) protects mice against lethal infection with A. suum larvae. It also inhibits growth of HT-29 human colorectal cancer cells (IC50 = 0.12 µM), halts the cell cycle at the G2/M phase, and induces apoptosis.
In an HT-29 mouse xenograft model, it inhibits peritoneal tumor growth when administered intraperitoneally at a dose of 150 mg/kg but not when administered orally. Albendazole inhibits mammalian tubulin polymerization and inhibits binding of [3H]mebendazole to H. contortus L3 larval tubulin (IC50s = 6.9 and 0.21 µM, respectively). Formulations containing albendazole have been used in the treatment of tapeworm infections and in a variety of nematode infections in livestock and pets.
Alternate Name | Methyl 5-(propylthio)-2-benzimidazolecarbamate |
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Appearance | White to off-white solid |
CAS # | 54965-21-8 |
Molecular Formula | C??H??N?O?S |
Molecular Weight | 265.33 |
Purity | ≥97% |
Solubility | DMSO |
SMILES | CCCSC1=CC2=C(C=C1)N=C(N2)NC(=O)OC |
InChi | InChI=1S/C12H15N3O2S/c1-3-6-18-8-4-5-9-10(7-8)14-11(13-9)15-12(16)17-2/h4-5,7H,3,6H2,1-2H3,(H2,13,14,15,16) |
InChi Key | HXHWSAZORRCQMX-UHFFFAOYSA-N |
PubChem CID | 2082 |
MDL Number | MFCD00083232 |
Handling | Protect from air and light |
Storage Conditions | -20°C |
Shipping Conditions | Gel Pack |
USAGE | For Research Use Only! Not For Use in Humans. |
CAS NO:57-83-0
CAS NO:57-83-0
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