Best Price 103-90-2 Paracetamol global

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1000 Kilogram	FOB Price:USD 29.0000 -30.0000

1000 Kilogram

FOB Price:USD 29.0000 -30.0000

Min.Order :1000 Kilogram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,Other

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Quick Details

Appearance:White Crystalline Powder
Application:Antipyretic and analgesics
PackAge:AS YOUR NEED
ProductionCapacity:1000|Kilogram|Day
Storage:A sealed container, cool and dry Away from fire and heat. Keep container closed
Transportation:by sea or air

Superiority:

Acetaminophen is an analgesic and antipyretic compound.Unlike many NSAIDs, which inhibit both COX-1 and COX-2, early studies suggested that acetaminophen is a poor inhibitor of both isoforms. However, it does inhibit COX-2 by 83% and COX-1 by 56% in human blood ex vivo, albeit at a high 1,000 mg dose, with IC₅₀ values of 25.8 and 113.7 µM, respectively.

Acetaminophen is enzymatically and non-enzymatically converted to several reactive metabolites that contribute to adverse or indirect effects, including liver injury. At toxic doses, the acetaminophen metabolite N-acetyl-4-benzoquinone imine depletes glutathione reserves in the liver, leading to an accumulation of NAPQI and subsequent hepatocyte necrosis. Acetaminophen decreases glutathione levels and reduces glutathione peroxidase activity in mice when administered at a dose of 250 mg/kg and induces ferroptotic cell death in primary mouse hepatocytes, an effect that can be blocked by the ferroptosis inhibitor ferrostatin-1 Acetaminophen has analgesic and antipyretic properties in animal models.

Details:

Acetaminophen is a Cox-1, Cox-2, and Cox-3 (cyclooxygenase) inhibitor. Acetaminophen may be selective for Cox-3 (IC₅₀ values are > 1000, > 1000, and 460 μM for murine Cox-1, murine Cox-2, and canine Cox-3, respectively). Acetaminophen is a widely used analgesic and antipyretic agent.

Catalogue Number	KIT2470
Chemical Name	Acetaminophen (1.0mg/mL in Methanol)
Synonyms	N-(4-Hydroxyphenyl)acetamide; 4’-Hydroxyacetanilide; 4-Acetamidophenol; N-Acetyl-4-aminophenol; APAP; Acamol; Acenol; Paracetamol; Paracetamole; Parageniol; Paralen; Paramol; Paraspen; Valadol; Valgesic; Vermidon;
CAS Number	103-90-2
Molecular Formula	C?H?NO?
Appearance	Colourless Solution
Molecular Weight	151.16
Storage	-20°C Freezer
Solubility	Methanol
Category	Standards; Pharmaceutical/API Drug Impurities/Metabolites; Solutions; Kits;
Applications	Acetaminophen is analgesic and antipyretic drug. It is a pain reliever commonly used to treat headache, muscle aches, arthritis, and other acute or chronic painful conditions.This compound is a contaminant of emerging concern (CECs).

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