98-92-0 Nicotinamide High Purity

Superiority:

Niacinamide is the active form of vitamin B3 and a component of the coenzyme nicotinamide adenine dinucleotide. Niacinamide acts as a chemo- and radio-sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia. This agent also inhibits poly(ADP-ribose) polymerases, enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy.

Nicotinamide is also called vitamin B3 or vitamin PP, is a kind of water-soluble vitamin, belong to B vitamin, as NAD (nicotinamide adenine dinucleotide, NAD) and NADP (nicotinamide adenine dinucleotide phosphate, NADP) composition, hydrogenation and dehydrogenation properties of nicotinamide in the body part of this two kinds of structure of coenzyme the reversible, play a role of hydrogen delivery in biological oxidation, can promote tissue respiration, biological oxidation process and the new supersedes the old, having a great significance in maintaining normal tissue, especially the integrity of the skin digestive tract and the nervous system. When the lack of B vitamins, due to respiration and metabolism of cells affected by pellagra, so this product is mainly used for the prevention and treatment of pellagra, stomatitis, glossitis and so on. In addition, this product has prevention of heart block and improving the sinoatrial node and anti-fast experimental arrhythmia function, can significantly improve Vera Pammy induced bradycardia and atrioventricular block. The clinical for coronary heart disease, viral myocarditis, rheumatic heart disease and a handful of digitalis poisoning associated with arrhythmia (mostly applied only when other medications fail), generally the degree atrioventricular block has obvious curative effect, basically after the treatment, all block can disappear, has obvious curative effect in sick sinus syndrome, right bundle branch block effect is poor. After the stomach intestinal absorption by the oral, intramuscular absorption faster, then absorption distribution to the body tissues, t1/2 is 45 min. The liver metabolism, most metabolize N-n-methylnicotinamide, only a small amount of treatment as the prototype from the urine was more than necessary. If the daily urinary excretion of N-methyl nicotinamide is lower than 4mg, suggesting that nicotinamide deficiency.