59277-89-3 Acyclovir price

Min.Order / FOB Price:Get Latest Price

500 Metric Ton	FOB Price:USD 58.0000 -60.0000

500 Metric Ton

FOB Price:USD 58.0000 -60.0000

Min.Order :500 Metric Ton
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,

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Quick Details

Appearance:White to light yellow crystal powder
Application:A synthetic acyclic purine nucleoside analog of the natural nucleoside 2′ deoxyguanosine, formulated for oral and topical use, and as the sodium salt for intravenous infusion
PackAge:25kg/drum
ProductionCapacity:1000|Kilogram|Day
Storage:Avoid contact with water
Transportation:by sea or air

Superiority:

Acyclovir is an antiviral compound that can be used to induce apoptosis in cells transfected with herpes simplex virus thymidine kinase (HSV-TK). The compound may exert inhibitory effects through the alterations of the cell cycle in leukemia cells lines, such as p185BCR-ABL expressing OM9:22 cells, by synchronizing the G₀/G₁ phase. Formation of acycloguanosine triphosphate occurs through the phosphorylation of HSV-TK and can inhibit the viral DNA polymerase. Acyclovir also has the ability to inhibit the proliferation of the fibroblast cells, NIH 3T3, transformed with v-abl or bcr-abl.

Acyclovir (Aciclovir) is a guanosine analogue and an orally active antiviral agent. Acyclovir inhibits HSV-1 (IC₅₀ of 0.85 μM), HSV-2 (IC₅₀ of 0.86 μM) and varicella-zoster virus. Acyclovir can be phosphorylated by viral thymidine kinase (TK), and Acyclovir triphosphate interferes with viral DNA polymerization through competitive inhibition with guanosine triphosphate and obligatory chain termination. Acyclovir prevents bacterial infections during induction therapy for acute leukaemia.

Details:

Acyclovir is an antiviral agent with activity against herpesvirus types 1 and 2 and varicella zoster virus. Acyclovir is converted by a herpesvirus enzyme into acyclovir triphosphate) that inhibits the synthesis of deoxyribonucleic acid (DNA) molecules in the virally infected cells, thereby inhibiting viral replication.

Catalogue Number	A192400
Chemical Name	Acyclovir
Synonyms	2-Amino-1,9-dihydro-9-[(2-hydroxyethoxy)methyl]-6H-purin-6-one; 9-[(2-Hydroxyethoxy)methyl]guanine; Acycloguanosine; Acicloftal; Cargosil; Gerpevir; Herpevir; Zovirax; Zyclir; Valaciclovir EP Impurity B;
Impurity	Valaciclovir EP Impurity B
CAS Number	59277-89-3
Molecular Formula	C?H??N?O?
Appearance	White to Off-White Solid
Melting Point	>240°C (dec.)
Molecular Weight	225.20
Storage	-20°C Freezer
Solubility	DMSO (Slightly), Methanol (Slightly)
Category	Standards; Pharmaceutical/API Drug Impurities/Metabolites; Anti-virals/Anti-retrovirals;
Applications	Acyclovir (Valaciclovir EP Impurity B) is an orally active acyclic nucleoside with inhibitory activity towards several herpes viruses. Antiviral.

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