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PENTOSTATIN Basic information |
Product Name: | PENTOSTATIN |
Synonyms: | PENTOSTATIN;(r)-3-(2-deoxy-beta-d-erythro-pento-furanosyl)-3,6,7,8-tetrahydroimidazo[4,5-d;(r)-3-(2-deoxy-beta-d-pentofuranosyl)-3,6,7,8-tetrahydroimidazo(4,5-d)(1,3)d;(r)-deoxycoformycin;(r)-rahydro;2’dcf;2’-deoxycoformycin;ci-825 |
CAS: | 53910-25-1 |
MF: | C11H16N4O4 |
MW: | 268.27 |
EINECS: | |
Product Categories: | Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;NULL |
Mol File: | 53910-25-1.mol |
PENTOSTATIN Chemical Properties |
Melting point | 154-157 C |
storage temp. | Store at +4°C |
PENTOSTATIN Usage And Synthesis |
Chemical Properties | White Solid |
Usage | Pentostatin is a potent antitumour antibiotic isolated from a Streptomyces species. Pentostatin is a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumour agent. |
Usage | Pentostatin is a potent antitumor antibiotic isolated from a Streptomyces species. Pentostatin is a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumor agent. |
Usage | An adenosine deaminase inhibitor used as an anti-cancer therapeutic drug. Shown to be effective in the treatment of hairy cell leukemia as well as having use in the treatment of other types of cancer such as chronic lymphocytic leukemia. |
Biological Activity | Irreversible inhibitor of adenosine deaminase (K i = 2.5 pM). Anticancer agent. |
PENTOSTATIN Preparation Products And Raw materials |
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PENTOSTATIN Basic information |
Product Name: | PENTOSTATIN |
Synonyms: | CL-67310465:NSC-218321;(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8β-ol;(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol;Coforin;2'-DeoxycoforMycin, Covidaribine, ADAI, CI 825, d-Cof, NSC 218321, PD-ADI, YK 176;Pentostatin(Deoxycoformycin);Pentostatin, >=99%;(R)-3-((2S,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol |
CAS: | 53910-25-1 |
MF: | C11H16N4O4 |
MW: | 268.27 |
EINECS: | |
Product Categories: | Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Protein Kinase Inhibitors and Activators;NULL |
Mol File: | 53910-25-1.mol |
PENTOSTATIN Chemical Properties |
Melting point | 154-157 C |
alpha | D25 +76.4° (c = 1 in water); D23 +73.0° (c = 1, pH 7 buffer) |
Boiling point | 411.43°C (rough estimate) |
density | 1.2576 (rough estimate) |
refractive index | 1.6081 (estimate) |
storage temp. | Store at +4°C |
solubility | H2O: soluble10mg/mL, clear |
pka | 5.2(at 25℃) |
color | white to beige |
PENTOSTATIN Usage And Synthesis |
Chemical Properties | White Solid |
Uses | Pentostatin is a potent antitumour antibiotic isolated from a Streptomyces species. Pentostatin is a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumour agent. |
Uses | Pentostatin is a potent antitumor antibiotic isolated from a Streptomyces species. Pentostatin is a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumor agent. |
Uses | An adenosine deaminase inhibitor used as an anti-cancer therapeutic drug. Shown to be effective in the treatment of hairy cell leukemia as well as having use in the treatment of other types of cancer such as chronic lymphocytic leukemia. |
Biological Activity | Irreversible inhibitor of adenosine deaminase (K i = 2.5 pM). Anticancer agent. |
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