Abacavir EP Impurity B with purity >98% in stock CAS 1443421-69-9

Details:

Product Name: Abacavir EP Impurity B

Chemical Name: N6-cyclopropyl-9-((1R,4S)-4-((2,5-diamino-6-chloropyrimidin-4-yloxy)methyl)cyclopent-2-enyl)-9H-purine-2,6-diamine

Molecular Formula: C18H21ClN10O

Molecular Weight: 428.88

CAS#: 1443421-69-9

Purity: >98%

Price: Negotiable

Available Document: COA, HPLC/GC, HNMR, qNMR, MS Spectrum

Payment Term: Payment in advance by T/T.

Shipment: Package will dispatched in 7-15 days(According to the date of payment) by air.

Trade Term: EXW, FOB, CFR, DDU, DDP, ect.

Abacavir EP Impurity B is an impurity of Abacavir. Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Abacavir is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The concentration of drug necessary to effect viral replication by 50 percent (EC50) ranged from 3.7 to 5.8 μM (1 μM = 0.28 mcg/mL) and 0.07 to 1.0 μM against HIV-1IIIB and HIV-1BaL, respectively, and was 0.26 ± 0.18 μM against 8 clinical isolates. Abacavir had synergistic activity in cell culture in combination with the nucleoside reverse transcriptase inhibitor (NRTI) zidovudine, the non-nucleoside reverse transcriptase inhibitor (NNRTI) nevirapine, and the protease inhibitor (PI) amprenavir; and additive activity in combination with the NRTIs didanosine, emtricitabine, lamivudine, stavudine, tenofovir, and zalcitabine.