Acebutolol EP Impur...

Acebutolol EP Impurity A with high purity CAS 28197-66-2
Acebutolol EP Impurity A with high purity CAS 28197-66-2
Acebutolol EP Impurity A with high purity CAS 28197-66-2
Acebutolol EP Impurity A with high purity CAS 28197-66-2
Acebutolol EP Impurity A with high purity CAS 28197-66-2

Acebutolol EP Impurity A with high purity CAS 28197-66-2

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10 Milligram

FOB Price: USD 50.0000

  • Min.Order :10 Milligram
  • Purity: 95%
  • Payment Terms : T/T

Keywords

Acebutolol EP Impurity A Acebutolol 28197-66-2

Quick Details

  • Appearance:White Solid
  • Application:For lab research use only
  • PackAge:Moisture-proof packing
  • ProductionCapacity:1|Gram|Week
  • Storage:Store at 2-8℃, dry, in dark
  • Transportation:by air

Superiority:

Topbatt Chemical Co., Ltd., Established in 2019, located in Shenzhen, Guangdong Province, is a Manufacturer and Trading company which specialized in fine chemicals like Pharmaceutical Reference Standards and Stable Isotopes. Our Stable Isotopes product line including 2H Labelled APIs, Reagents and Intermediates, 13C Labelled Substance, 15N Labelled Substance and 18O Labelled Substance.

We own a number of Senior pharmaceutical synthetic engineer, analysis engineer and analytical testing instrument. It make us have more than 1700 varieties compouds with high purity in stock in a short time.

We can provide you not only stock items, but also Custom Synthesis Service.

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Details:

Product Name: Acebutolol EP Impurity A

Chemical Name: N-(3-acetyl-4-(oxiran-2-ylmethoxy)phenyl)butyramide

Molecular Formula: C15H19NO4

Molecular Weight: 277.32

CAS#: N/A

Purity: 95%

Price: Negotiable

 

Available Document: COA, HPLC/GC, HNMR, qNMR, MS Spectrum

Payment Term: Payment in advance by T/T.

Shipment: Package usally dispatched in 7-15 days(According to the date of payment) by air.

Trade Term: EXW, FOB, CFR, DDU, DDP, ect.

 

Acebutolol EP Impurity A is an impurity of Acebutolol. Acebutolol is a beta blocker for the treatment of hypertension and arrhythmias. Acebutolol following single intravenous administration (10 mg/kg) to rat results in the plasma clearance of 61.9 mL/min/kg, the volume of distribution of 9.6 L/kg, and an elimination half-life of 1.8 hours. Acebutolol following single intravenous administration (50 mg/kg) to rat results in the plasma clearance of 46.5 mL/min/kg, the volume of distribution of 9.5 L/kg, and an elimination half-life of 2.3 hours[1].Acebutolol (30 mg/kg) decreases cardiac output by 65% and 31% after 1 min and 10 min measurements, respectively, in Sprague-Dawley rats. Acebutolol (30 mg/kg) significantly reduces regional blood flow (RBF) in most organs either after 1 min or 10 min measurements when compare with the baseline values in Sprague-Dawley rats[3].

References:
[1]. Piquette-Miller, M. and F. Jamali, Pharmacokinetics and multiple peaking of acebutolol enantiomers in rats. Biopharm Drug Dispos, 1997. 18(6): p. 543-56.
[2]. Mostafavi, S., R. Lewanczuk, and R. Foster, Influence of acebutolol and metoprolol on cardiac output and regional blood flow in rats. Biopharm Drug Dispos, 2000. 21(4): p. 121-8.
[3]. Bristow MR, et al. Treatment of chronic heart failure with β-adrenergic receptor antagonists: a convergence of receptor pharmacology and clinical cardiology. Circ Res. 2011 Oct 28;109(10):1176-94.

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