CasNo.74143-33-2,Acebutolol EP Impurity K with high purity CAS 74143-33-2,(74143-33-2) Suppliers

10 Milligram	FOB Price: USD 50.0000

Min.Order :10 Milligram
Purity: 95%
Payment Terms : T/T

Keywords

Acebutolol EP Impurity K Acebutolol 74143-33-2

Quick Details

Appearance:Light Yellow Solid
Application:For lab research use only
PackAge:Moisture-proof packing
ProductionCapacity:1|Gram|Week
Storage:Store at 2-8℃, dry, in dark
Transportation:by air

Superiority:

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Details:

Product Name: Acebutolol EP Impurity K

Chemical Name: N-(3-butyryl-4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)butyramide

Molecular Formula: C20H32N2O4

Molecular Weight: 364.49

CAS#: 74143-33-2

Purity: 95%

Price: Negotiable

Available Document: COA, HPLC/GC, HNMR, qNMR, MS Spectrum

Payment Term: Payment in advance by T/T.

Shipment: Package usally dispatched in 7-15 days(According to the date of payment) by air.

Trade Term: EXW, FOB, CFR, DDU, DDP, ect.

Acebutolol EP Impurity K is an impurity of Acebutolol. Acebutolol is a beta blocker for the treatment of hypertension and arrhythmias. Acebutolol following single intravenous administration (10 mg/kg) to rat results in the plasma clearance of 61.9 mL/min/kg, the volume of distribution of 9.6 L/kg, and an elimination half-life of 1.8 hours. Acebutolol following single intravenous administration (50 mg/kg) to rat results in the plasma clearance of 46.5 mL/min/kg, the volume of distribution of 9.5 L/kg, and an elimination half-life of 2.3 hours[1].Acebutolol (30 mg/kg) decreases cardiac output by 65% and 31% after 1 min and 10 min measurements, respectively, in Sprague-Dawley rats. Acebutolol (30 mg/kg) significantly reduces regional blood flow (RBF) in most organs either after 1 min or 10 min measurements when compare with the baseline values in Sprague-Dawley rats[3].

References:

[1]. Piquette-Miller, M. and F. Jamali, Pharmacokinetics and multiple peaking of acebutolol enantiomers in rats. Biopharm Drug Dispos, 1997. 18(6): p. 543-56.

[2]. Mostafavi, S., R. Lewanczuk, and R. Foster, Influence of acebutolol and metoprolol on cardiac output and regional blood flow in rats. Biopharm Drug Dispos, 2000. 21(4): p. 121-8.

[3]. Bristow MR, et al. Treatment of chronic heart failure with β-adrenergic receptor antagonists: a convergence of receptor pharmacology and clinical cardiology. Circ Res. 2011 Oct 28;109(10):1176-94.

Acebutolol EP Impur...