High quality Isoniazid

Details:

1.Product description

Product Name: Isoniazid

CAS: 54-85-3

MF: C6H7N3O

MW: 137.14

EINECS: 200-214-6



2.Physical properties

White crystalline powder

mp 171-173 °C(lit.)

Fp >250°C

storage temp. Refrigerator

Water Solubility 14 g/100 mL (25 oC)

Sensitive Air Sensitive

Merck 14,5186

BRN 119374

Stability: Stability Stable, but may be air or light sensitive. Combustible. Incompatible with strong oxidizing agents, chloral, aldehydes, iodine, ferric salts, hypochlorites.





3.Specification



Test Item

Analysis Specification

Result

Description

crystalline powder

Conforms

Melting range

129°C~132°C

130.8°C-131°C

Loss on drying

≤0.5%

0.20 %

Specific rotation

-58°~-62°(C=1,in CH3OH)

-61.05°

Sulphated ash

≤0.1%

0.08 %

Heavy metals

≤10ppm

Conforms

Chlorides

≤0.02%

Conforms

Sulfates

≤0.02%

Conforms

Fluorine

14.7%~17.9%

15.2%

Residual solvent

Methanol ≤0.2%

Isopropanol ≤0.2%

Ethyl acetate≤0.2%

Chloroform ≤0.2%

0.0%

0.0%

0.0%

0.0%

Related substances

(HPLC)

Single impurity ≤0.2%

Total impurities ≤0.5%

0.05%

0.08%

Assay

≥99.5%

99.92%

Conclusion

Accordance with the reference









4.Application

antibacterial, tuberculostatic

Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Sele ctively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antib acterial (tuberculostatic).

For the treatment of all forms of tuberculosis in which organisms are susceptible.