factory CAS 5470-11-1 Hot Sale 5470-11-1

Min.Order / FOB Price:Get Latest Price

1 Kilogram	FOB Price:USD 4.8000 -5.0000

1 Kilogram

FOB Price:USD 4.8000 -5.0000

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : L/C,T/T,Other

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factory CAS 5470-11-1 Hot Sale 5470-11-1 5470-11-1 Direct Manufacturer

Quick Details

Appearance:White crystal or granular crystal
Application:It is used as raw material of medicine and organic synthesis, reducing agent and imaging agent
PackAge:25kgs/fiber drum ,or according to the requirements of the customers
ProductionCapacity:2000|Metric Ton|Year
Storage:Keep undercool, dry and well ventilated warehouses, guard against fire
Transportation:by sea or by air

Superiority:

factory CAS 5470-11-1 Hot Sale 5470-11-1

The preparation methods

[Method 1]

The preparation method is to add water into the reactor, add sodium nitrite under agitation, add sodium metabisulfite, and then acidify with sulfuric acid. The acidified material was fed into the hydrolysis kettle, acetone was added, and then neutralized with liquid alkali, and the neutralized liquid was distilled to obtain acetone oxime. Acetone oxime and hydrochloric acid were added into the salt kettle to react to form hydroxylamine hydrochloride and acetone. Acetone recovery and use; Hydroxylamine hydrochloride through concentration, cooling crystallization, centrifugal separation, drying, can be finished. Reaction equation: NaNO2[NaHSO3]→[H2SO4]HON(SO3Na)2[(CH3)2CH]→HON=C(CH3)2[HCl]→NH2OH·HCl

Another method of production is the nitromethane process. Hydroxylamine hydrochloride was prepared by reaction of nitromethane with hydrochloric acid. Reaction equation: CH3NO2[HCl]→[H2O]NH2OH·HCl

[Method 2]

The oximation method first adds a certain amount of water, a certain amount of sodium nitrite under agitation, and a certain amount of sodium metabisulfite, and then acidifies with sulfuric acid. After acidification, the material liquid was fed into the hydrolytic kettle, a certain amount of acetone was added, and then the liquid alkali was added for neutralization. The neutralizing liquid is drawn into the distillation kettle to distill acetone oxime. Acetone oxime and hydrochloric acid of a certain ratio were added into the salt concentration kettle for reaction to produce hydroxylamine hydrochloride and acetone. Acetone recovery for water supply. Hydroxylamine hydrochloride was concentrated, cooled, crystallized, centrifuged and dried to produce hydroxylamine hydrochloride finished products. its

Nahso3 Na2S2O5 + H2O - > 2

NaNO2 + 2 nahs3 - HON (SO3Na) 2 + NaOH

NaOH + - H2SO4 - NaHSO4 + H2O

HON (SO3Na) 2 + co + H2O (CH3) 2 - (CH3) 2 cnoh nahso4 + 2

(CH3) 2 cnoh + HCl + H2O and NH2OH · HCl + (CH3) 2 co

[Method 3]

1. Sodium nitrite synthesis (oximation method) Add water to the reactor, add sodium nitrite under agitation, add sodium pyrosulfite in stages, and then acidify with sulfuric acid. The acidified material was fed into the hydrolysis kettle, acetone was added, and then neutralized with liquid alkali, and the neutralized liquid was distilled to obtain acetone oxime. Acetone oxime and hydrochloric acid were added into the salt kettle to react to form hydroxylamine hydrochloride and acetone. Acetone recovery and use; Hydroxylamine hydrochloride through concentration, cooling crystallization, centrifugal separation, drying, can be finished. Raw material consumption norm: sodium nitrite (95%) 1970kg/t, sodium metabisulfite (64% SO2) 5418kg/t, acetone (98%) 1175kg/t. 2. Nitromethane process nitromethane interacts with hydrochloric acid and water to produce hydroxylamine hydrochloride. According to HGB3044-76, hydroxylamine hydrochloride product is white crystal, the content of grade 2 product ≥98.5, the content of grade 3 product ≥97%. Raw material consumption quota: nitromethane 1200kg/t, hydrochloric acid (30%) 1500kg/t.

Details:

[Protective Measures]

This product is highly toxic and irritating to the skin. The oral LD50 of mice was 400mg/kg. Production equipment should be sealed to prevent running, bubbling, dripping and leakage. Operators should wear protective equipment. Flush with plenty of water when splash and skin.

[General Method]

The inner layer is lined with plastic bags, the middle layer is lined with paper bags, the outer layer is woven with polyethylene bags, and then packed in wooden buckets or paper buckets, each bag is 25kg. This product is easy to absorb moisture and can be deeply decomposed when heated, so it needs to be sealed and stored in a dry place, moisture-proof and heat-proof. Store and transport according to the regulations on toxic substances.

Hydroxylamine hydrochloride is mainly used as reducing agent and imaging agent, used in organic synthesis to prepare oxime, and also used as raw materials for synthesis of anti-cancer drugs (hydroxurea), sulfamethoxazole and pesticide (Methomyl).

The physical and chemical properties

Colorless crystal, delirious,

Density: 1.67.

Melting point :152℃(decomposition). Soluble in water, ethanol, glycerin, not soluble in ether. Colorless monoclinic crystal. 1.67 g/cm3 density (17 ℃).

Soluble in hot water, alcohol, propylene glycol, insoluble in ether. High hygroscopicity, higher than 151℃ moisture decomposition.

Toxicity: This product is poisonous and irritating to the skin. The median lethal dose (oral) was 408mg/kg. Corrosive. Production equipment should be sealed to prevent running, bubbling, dripping and leakage. Operators should wear protective equipment. Flush with plenty of water when splash and skin.

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