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Clobetasol Propionate Raw Material Clobetasol Propionate Clobetasol Propionate 25122-46-7
Introduction:
Clobetasol propionate 25122-46-7 is one of the highly effective topical corticosteroids in clinical application.Its anti-inflammatory effect was f 5 times that of hydrocortisone, 2.3 times that of tamasone sodium phosphate, and 18.7 times that of fluoridium.The systemic adverse reaction is 3 times of fluorine relaxed.Clobetasol propionate has anhydrous sodium retention function and has certain promotion sodium, potassium excretion function
Function
1.Clobetasol propionate 25122-46-7 has anti-inflammatory effects which can reduce and prevent tissue response to inflammation, thereby reducing inflammation performance.
2..Clobetasol propionate has immunosuppressive effect which can prevent or inhibit cell-mediated immune response, delayed hypersensitivity reactions, reducing T lymphocytes, monocytes, eosinophils, reducing immunoglobulin binding to cell surface receptors and inhibition of the synthesis and release of interleukin, thus reducing the T lymphocyte transformation of lymphoblastoid cells, and reduce the extension of the primary immune response.
APPLICATIONS
Clobetasol propionate 25122-46-7 is mostly used in pharmaceuticals industry
Xi'an Kono chem co.Ltd.,founded in 2014,is a holding enterprise of Hong Kong PIONEER BIOTECH GROUP.It is an export-oriented
manufacturring enterprise supported by the Ministry of Commerce.
Kono chem is located in Xi'an,Shaanxi Province,equipped with a number of engineers inPharmaceutical,Nutrition,Bioengineering,commit-ted themselves to create products that meet customer requirments.At present,Kono's main products cover pharmaceutical,food,cosmetics
scientific research.
Test |
Specifications |
Result |
Assay(HPLC,basis on drying) |
97.0~102.0% |
99.4% |
Appearance |
White or almost white crystalline powder |
almost white crystalline powder |
Solubility |
Practically insoluble in water,slightly soluble in benzene and diethyl ether ,sparingly soluble ethanol, soluble in acetone and in dimethyl sulfoxide, in chloroform, in methanol and in dioxane |
Complies |
Identification (IR) |
Complies with the Standard |
Complies |
Melting point |
about 196℃ |
194.0~195.0℃ |
Loss on drying |
Max.2.0% |
0.07% |
Residue on ignition |
max. 0.1% |
0.06% |
Heavy Metals |
max.20ppm |
Complies |
Related Substances (HPLC) |
-Singel impurity N.m.t 1.0% |
0.39% |
|
-Sum impurity N.m.t 2.5% |
0.46% |
Organic volatile impurities |
||
As |
<3ppm |
Complies |
THF |
Not more than 720ppm |
Complies |
Methanol |
Not more than 3000ppm |
Complies |
DMF |
Not more than 880ppm |
Complies |
Pyridine |
Not more than 200ppm |
Complies |
Dichloromethane |
Not more than 600ppm |
Complies |
Ethanol |
Not more than 5000ppm |
Complies |
Acetone |
Not more than 5000ppm |
Complies |
Conclusion:The test product complies with the requirements of USP41. |
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