CasNo.22457-89-2,98% Benfotiamine 22457-89-2,(22457-89-2) Suppliers

1 Kilogram	FOB Price:USD 205.0000 -220.0000

Min.Order :1 Kilogram
Purity: 50%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

22457-89-2 Benfotiamine 98% Benfotiamine

Quick Details

Appearance:White to off-white powder
Application:for pharma use
PackAge:drum and bag
ProductionCapacity:1000|Kilogram|Month
Storage:in sealed air resistant place
Transportation:by sea or air

Superiority:

Superiority

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Details:

98% Benfotiamine 22457-89-2

Benfotiamine is vitamin B1 fat soluble derivatives, improve the bioavailability of water-soluble vitamin B1 low shortcomings, improve the blood and tissue concentrations of thiamine, so as to improve the curative effect. Benfotiamine is primarily marketed as an antioxidant dietary supplement.

Benfotiamine: N-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-N-(4-hydroxy-2-mercapto-1-methyl-1-butenyl)formamide-S-benzoate dihydrogen phosphate

Molecular Structure:

Molecular Formula:C19H23N4O6PS

Molecular Weight:466.45

CAS No.: 22457-89-2

EINECS:245-013-4

Appearance: White crystalline powder

Solubility: insoluble in water

Packing: 25kg/Fibre drum;

Storage:Avoid light, and preserved hermetically.

Certificate of Analysis

Test	Specifications	Result
Assay	≥98.0%	Complies
Appearance	A white to off-white crystalline powder	Complies
Identification	IR
Water	≤ 1.5%	0.4%
Chloride	≤0.053%	0.031%
Sulphate	≤0.011%	0.005%
Thiamine	≤0.1%	0.06%
Benzoic acid	Negative	Complies
Melting point	≤ 200℃	Complies
Heavy metal	≤ 20ppm	<10ppm
Conclusion	Conform with In house Standard

Function&Application

Benfotiamine is useful for the treatment of diabetic retinopathy, neuropathy, and nephropathy however "Most of the effects attributed to benfotiamine are extrapolated from in vitro and animal studies. Unfortunately apparent evidences from human studies are scarce and especially endpoint studies are missing. Therefore additional clinical studies are mandatory to explore the therapeutic potential of benfotiamine in both diabetic and non-diabetic pathological conditions".

It is thought that treatment with benfotiamine leads to increased intracellularthiamine diphosphate levels, a cofactor of transketolase. This enzyme directs advanced glycation and lipoxidation end products (AGE's, ALE's) substrates to the pentose phosphate pathway, thus reducing tissue AGEs.

1. Benfotiamine is used for the prevention and treatment of vitamin B1 deficiency;

2. For vitamin B1 demand increase, with inadequate intake from foods supplies (fatigue, hyperthyroidism, pregnancy, lactation, during strenuous manual labor, etc.);

3. Benfotiamine is used in the treatment of non alcoholic wernicke encephalopathy;

4. To treat beriberi;

5. Used in the following diseases, speculation and vitamin B1 deficiency and metabolic disorders associated with treatment, such as: neuralgia; Muscle pain, joint pain; Peripheral neuritis, peripheral nerve palsy; Myocardial metabolic disorders; Constipation and other gastrointestinal motor function obstacle.