Supply 103-63-9 (2-...

Supply 103-63-9 (2-Bromoethyl)benzene best quality 103-63-9 (2-Bromoethyl)benzene
Supply 103-63-9 (2-Bromoethyl)benzene best quality 103-63-9 (2-Bromoethyl)benzene

Supply 103-63-9 (2-Bromoethyl)benzene best quality 103-63-9 (2-Bromoethyl)benzene

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1 Kilogram

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  • Min.Order :1 Kilogram
  • Purity: 99%
  • Payment Terms : L/C,T/T,Other

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Supply 103-63-9 (2-Bromoethyl)benzene best quality 103-63-9 (2-Bromoethyl)benzene 103-63-9 (2-Bromoethyl)benzene manufacturer

Quick Details

  • Appearance:Colorless to slight yellow clear liquid
  • Application:Used as intermediate of medicine and pesticide.
  • PackAge:250kg/Plastic drum,or according to the requirements of the customers
  • ProductionCapacity:2000|Metric Ton|Year
  • Storage:Keep undercool, dry and well ventilated warehouses, guard against fire
  • Transportation:by sea or by air

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Supply 103-63-9 (2-Bromoethyl)benzene

best quality 103-63-9 (2-Bromoethyl)benzene

【 English Name 】
 
1-BROMO-2-PHENYLETHANE
(2-BROMOETHYL)BENZENE
2-PHENYLETHYL BROMIDE
BETA-BROMOETHYL BENZENE
BETA-BROMOPHENYLETHANE
B-PHENYLETHYL BROMIDE
BROMOETHYLBENZENE(2-)
PHENETHYL BROMIDE
PHENYL ETHYL BROMIDE
(2-bromoethyl)-benzen
.beta.-Phenylethylbromide
2-Phenethyl bromide
2-phenethylbromide
2-Phenyl-1-bromoethane
Benzene, (2-bromoethyl)-
Benzene,(2-bromoethyl)-
benzene,2-bromoethyl-
beta.-Phenylethylbromide
beta-Phenethyl bromide
beta-phenethylbromide
 
Introduction to the
β-bromophenylethane is an important intermediate for the synthesis of high efficiency brominated flame retardant polystyrene brominated, and is often used in the preparation of organic synthesis intermediates. For example, β-bromophenylethane can be used for the preparation of premister intermediate 4-(4-phenylbutoxy) benzoic acid. Premast was first developed by Ono in Japan as an anti-asthma drug, and was marketed in Japan in 1995. In 1999, it was found to treat allergic rhinitis. Prenast is a leukotriene C4/D4 receptor antagonist antibody (LTRAS) with very low toxicity. It can selectively inhibit the leukotriene skin activity of airway smooth muscle, and has almost no effect on arachidonic acid metabolic enzymes. At the same time, it has no antagonistic effect on acetylcholine and 5-hydroxytryptamine, and has significant inhibition on LTC4, LTD4 and LTE4.
 
Chemical properties
Colorless liquid. Melting point -56℃, boiling point 220-221℃, 217-218℃ (97.62kPa), 92℃ (1.46kPa), relative density 1.3589, refractive index 1.5572. Can be miscible with ether, benzene, insoluble in water. Flash point is 89 ℃.
 
use
Organic synthesis, pesticide intermediate. Used as medicine and pesticide intermediate
 
Production methods
It's made by reacting phenylethanol with hydrogen bromide. The phenylethanol was heated to 110℃, and then hydrogen bromide was slowly added to reflux reaction. After the reaction, cool down and wash with water, 10% sodium carbonate solution and water in turn. After drying with anhydrous potassium carbonate, decompression fractionation was used to collect the fraction at 97-99℃ (2.0kPa), and the yield was above 90%.

 

Details:

【Appearance properties】 Colorless liquid. Melting point -56℃, boiling point 220-221℃, 217-218℃ (97.62kPa), 92℃ (1.46kPa), relative density 1.3589, refractive index 1.5572. Can be miscible with ether, benzene, insoluble in water. Flash point is 89 ℃.
【Melting point】 -56 °C
【 boiling point 】220-221 °C(lit.)
【 Density 】1.355 g/mL at 25 °C(lit.)
【flash point】193 °F
【Water solubility 】INSOLUBLE
【 BRN 】 507487
【Introduction】 β-bromophenylethane is an important intermediate for the synthesis of high efficiency brominated flame retardant polystyrene brominated, and is often used in the preparation of organic synthesis intermediates. For example, β-bromophenylethane can be used for the preparation of premister intermediate 4-(4-phenylbutoxy) benzoic acid.
Premast was first developed by Ono in Japan as an anti-asthma drug, and was marketed in Japan in 1995. In 1999, it was found to treat allergic rhinitis. Prenast is a leukotriene C4/D4 receptor antagonist antibody (LTRAS) with very low toxicity. It can selectively inhibit the leukotriene skin activity of airway smooth muscle, and has almost no effect on arachidonic acid metabolic enzymes. At the same time, it has no antagonistic effect on acetylcholine and 5-hydroxytryptamine, and has significant inhibition on LTC4, LTD4 and LTE4.
 
The preparation methods
It's made by reacting phenylethanol with hydrogen bromide. The phenylethanol was heated to 110℃, and then hydrogen bromide was slowly added to reflux reaction. After the reaction, cool down and wash with water, 10% sodium carbonate solution and water in turn. After drying with anhydrous potassium carbonate, decompression fractionation was used to collect the fraction at 97-99℃ (2.0kPa), and the yield was above 90%.

 

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