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5-Aminosalicylic acid Basic information

Overview Indication Mode of action Pharmacokinetics Adverse reactions and toxicity References

Product Name: 5-Aminosalicylic acid

Synonyms: 5-Aminosalicylic acid, 98.5%, IKK inhibitor;2-HYDROXY-5-AMINOBENZOIC ACID;3-Carboxy-4-hydroxyaniline;5-AMINO-2-HYDROXYBENZOIC ACID;5-AMINOSALICYLIC ACID;5-ASA;5-AS;rowasa

CAS: 89-57-6

MF: C7H7NO3

MW: 153.14

EINECS: 201-919-1

Product Categories: API;CITANEST;Pharmaceuticals;Carboxylic Acids;Aromatics;Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Carboxylic Acids;Phenyls & Phenyl-Het;Organic acids;Various Metabolites and Impurities;Fendosal;Intermediates & Fine Chemicals;Phenyls & Phenyl-Het;Fluorescent;FINE Chemical & INTERMEDIATES;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Metabolites & Impurities

Mol File: 89-57-6.mol

5-Aminosalicylic acid Structure

5-Aminosalicylic acid Chemical Properties

Melting point 275-280 °C (dec.)(lit.)

Boiling point 276.03°C (rough estimate)

density 1.3585 (rough estimate)

refractive index 1.5500 (estimate)

Fp 279-281°C

storage temp. 2-8°C

solubility Soluble in dimethyl sulfoxide.

form tablets

pka 2.74, 5.84(at 25℃)

color off-white to gray

PH 4.0-4.1 (0.8g/l, H2O, 20℃)

PH Range Non-B uorescence (3.1) to light green B uorescence (4.4)

Water Solubility <0.1 g/100 mL at 21 ºC

Decomposition 279-281 ºC

Merck 14,5904

BRN 2090421

Stability: Stable. Incompatible with acids, acid anhydrides, acid chlorides, chloroformates, strong oxidizing agents.

Major Application Detergent, hair dyes, prevention of colorectal cancer, treating inflammatory bowel disease, autoimmune disorders, gastrointestinal inflammation, chemokine-mediated diseases, mucosal tissue disorder, sleep disorders, rectoanal tenesmus, ulcerative colitis

InChIKey KBOPZPXVLCULAV-UHFFFAOYSA-N

CAS DataBase Reference 89-57-6(CAS DataBase Reference)

NIST Chemistry Reference Mesalamine(89-57-6)

EPA Substance Registry System Benzoic acid, 5-amino-2-hydroxy- (89-57-6)